HitPredict

Interactor 1: GRAP (Q13588)
GRB2-related adapter protein
Gene: GRAP

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10391903
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 676
+	Hs
		924959 GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Mm
		1114082 GRB2_MOUSE (1-216): 3.23e-69: 212: 59.72		Q3ZB59_MOUSE (1-676): 0: 714: 91.31
+	Mm
		1141175 GRB2_MOUSE (1-216): 3.23e-69: 212: 59.72		GAB2_MOUSE (1-676): 0: 714: 91.16
+	Mm
		69824 B1AT92_MOUSE (1-216): 1.28e-63: 197: 56.94		GAB2_MOUSE (1-676): 0: 714: 91.16
+	Hs
		924547 GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		1141170 GRB2_MOUSE (1-216): 3.23e-69: 212: 59.72		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		442825 HCK_HUMAN (4-158): 6.34e-52: 176: 32.74		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		411709 LCK_HUMAN (4-204): 1.02e-41: 149: 26.98		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		846468 BLK_HUMAN (4-204): 4.54e-41: 147: 23.83		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		433345 YES_HUMAN (3-217): 1.29e-37: 138: 24.05		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		924730 GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72		GAB3_HUMAN (3-667): 7.57e-162: 479: 31.42
+	Hs
		337512 ABL1_HUMAN (3-180): 4.01e-52: 182: 31.69		GAB3_HUMAN (3-667): 7.57e-162: 479: 31.42
+	Hs
		924640 GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Hs
		411764 LCK_HUMAN (4-204): 1.02e-41: 149: 26.98		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Hs
		924876 GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72		PKHA2_HUMAN (2-229): 1.67e-55: 197: 21.55
+	Dm
		993221 GRAP_DROME (1-216): 2.57e-58: 184: 53.24		DOS_DROME (8-218): 1.26e-36: 149: 30.22
+	Hs
		924702 GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72		SESQ1_HUMAN (2-132): 1.35e-28: 116: 22.63
+	Dm
		993229 GRAP_DROME (1-216): 2.57e-58: 184: 53.24		X2JFU3_DROME (9-119): 3.8e-24: 104: 24.32
+	Hs
		411861 LCK_HUMAN (4-204): 1.02e-41: 149: 26.98		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		411765 LCK_HUMAN (4-204): 1.02e-41: 149: 26.98		PHLB3_HUMAN (9-121): 9.24e-25: 111: 28.07