HitPredict

Interactor 1: TRA2A (Q13595)
Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A)
Gene: TRA2A

Interactor 2: RNPS1 (Q15287)
RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)
Gene: RNPS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	32296183, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, validated two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 282 Hs			1 305
+	Hs
		516744 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		516502 TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		1031507 PABP4_HUMAN (1-267): 6.75e-38: 142: 14.13		RBM8A_HUMAN (95-239): 7.02e-31: 115: 21.38
+	Hs
		516768 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		RBM8A_HUMAN (95-239): 7.02e-31: 115: 21.38
+	Hs
		516425 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06
+	Hs
		853881 PABP4_HUMAN (1-267): 6.75e-38: 142: 14.13		NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06
+	Hs
		925043 TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		925150 TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		1031314 TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00		PABP4_HUMAN (153-248): 4.98e-19: 89.2: 27.08
+	Hs
		474022 TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00		PAB4L_HUMAN (161-242): 1.56e-18: 86.5: 30.49
+	Hs
		516339 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		516495 PABP4_HUMAN (1-267): 6.75e-38: 142: 14.13		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		198939 PPIL4_HUMAN (117-195): 7.73e-27: 110: 39.24		RFOX2_HUMAN (44-274): 2.32e-31: 122: 13.25
+	Hs
		474021 PABP4_HUMAN (1-267): 6.75e-38: 142: 14.13		PAB4L_HUMAN (161-242): 1.56e-18: 86.5: 30.49
+	Hs
		516471 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		TIAR_HUMAN (155-250): 1.9e-18: 86.5: 27.08
+	Hs
		198809 MSI1H_HUMAN (100-255): 8.46e-26: 106: 22.22		RFOX2_HUMAN (44-274): 2.32e-31: 122: 13.25
+	Hs
		516689 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		PABP3_HUMAN (153-248): 4.53e-17: 83.4: 26.04
+	Hs
		516451 TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32