HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	27716508, 30190310
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005829 - cytosol GO:0006513 - protein monoubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 568
+	Rn
		70072 B1WBY1_RAT (1-776): 0: 912: 99.87		KLH17_RAT (11-566): 1.56e-162: 479: 40.75
+	Hs
		1040975 CUL1_HUMAN (1-776): 0: 911: 100.00		KEAP1_HUMAN (8-564): 2.73e-161: 475: 35.88
+	Hs
		1043391 CUL4B_HUMAN (7-776): 0: 773: 29.90		KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00
+	Hs
		1041712 CUL3_HUMAN (9-776): 0: 748: 30.47		KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00
+	Hs
		1042971 CUL4A_HUMAN (7-776): 0: 781: 30.41		KEAP1_HUMAN (8-564): 2.73e-161: 475: 35.88
+	Hs
		1041852 CUL3_HUMAN (9-776): 0: 748: 30.47		KLH17_HUMAN (11-566): 1.87e-162: 479: 40.40
+	Rn
		78189 CUL3_RAT (9-776): 0: 748: 30.35		KLH17_RAT (11-566): 1.56e-162: 479: 40.75
+	Hs
		1041547 CUL3_HUMAN (9-776): 0: 748: 30.47		KEAP1_HUMAN (8-564): 2.73e-161: 475: 35.88
+	Hs
		299515 CUL3_HUMAN (9-776): 0: 748: 30.47		KLH18_HUMAN (5-565): 1.58e-159: 469: 39.79
+	Hs
		307170 CUL3_HUMAN (9-776): 0: 748: 30.47		KLHL2_HUMAN (13-567): 3.8e-158: 466: 41.36
+	Hs
		1041189 CUL1_HUMAN (1-776): 0: 911: 100.00		KLHL4_HUMAN (360-567): 9.8e-58: 207: 36.54
+	Hs
		1041237 CUL1_HUMAN (1-776): 0: 911: 100.00		KLH13_HUMAN (380-568): 2.64e-43: 165: 28.06
+	Hs
		152488 CUL1_HUMAN (1-776): 0: 911: 100.00		ENC1_HUMAN (378-568): 9.99e-32: 131: 21.29
+	Hs
		1041193 CUL1_HUMAN (1-776): 0: 911: 100.00		KLH25_HUMAN (471-567): 4.6e-11: 67.5: 16.33
+	Hs
		1043271 CUL4A_HUMAN (7-776): 0: 781: 30.41		KLHL9_HUMAN (380-568): 3.91e-43: 164: 27.55
+	Hs
		1043281 CUL4A_HUMAN (7-776): 0: 781: 30.41		KLHL3_HUMAN (422-568): 1.81e-34: 139: 36.05
+	Hs
		1041807 CUL3_HUMAN (9-776): 0: 748: 30.47		KLH10_HUMAN (428-568): 1.65e-33: 136: 33.80
+	Hs
		152489 CUL3_HUMAN (9-776): 0: 748: 30.47		ENC1_HUMAN (378-568): 9.99e-32: 131: 21.29
+	Hs
		1041718 CUL3_HUMAN (9-776): 0: 748: 30.47		KLH26_HUMAN (365-568): 5.54e-30: 126: 23.26
+	Hs
		1041853 CUL3_HUMAN (9-776): 0: 748: 30.47		KLH24_HUMAN (394-568): 1.15e-28: 122: 29.67