HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBW10 (Q5XX13)
F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor)
Gene: FBXW10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36990424
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 1052
+	Mm
		1257398 CUL1_MOUSE (1-776): 0: 912: 99.87		FBXW7_MOUSE (40-516): 4.22e-39: 158: 12.28
+	Hs
		1041133 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXW7_HUMAN (40-516): 5.06e-39: 157: 12.28
+	Mm
		1112933 CUL1_MOUSE (1-776): 0: 912: 99.87		FBW1A_MOUSE (29-448): 4.19e-35: 144: 10.44
+	Hs
		1041292 CUL1_HUMAN (1-776): 0: 911: 100.00		FBW1A_HUMAN (604-838): 1.88e-28: 124: 7.34
+	Hs
		903206 CUL1_HUMAN (1-776): 0: 911: 100.00		WDR5_HUMAN (123-437): 8.37e-21: 96.9: 10.98
+	Hs
		1041266 CUL1_HUMAN (1-776): 0: 911: 100.00		FBW1B_HUMAN (602-752): 1.09e-16: 86.5: 12.58
+	Hs
		245601 CUL4B_HUMAN (7-776): 0: 773: 29.90		TBL1X_HUMAN (514-840): 6.11e-51: 191: 11.59
+	Hs
		1043499 CUL4B_HUMAN (7-776): 0: 773: 29.90		FBXW7_HUMAN (40-516): 5.06e-39: 157: 12.28
+	Hs
		1043114 CUL4A_HUMAN (7-776): 0: 781: 30.41		POC1B_HUMAN (561-1019): 5.27e-33: 136: 11.23
+	Hs
		1043469 CUL4B_HUMAN (7-776): 0: 773: 29.90		POC1B_HUMAN (561-1019): 5.27e-33: 136: 11.23
+	Hs
		1043319 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBW1A_HUMAN (604-838): 1.88e-28: 124: 7.34
+	Hs
		792982 CUL4A_HUMAN (7-776): 0: 781: 30.41		LIS1_HUMAN (157-483): 7.95e-28: 119: 12.13
+	Hs
		152876 CUL4B_HUMAN (7-776): 0: 773: 29.90		APAF_HUMAN (654-871): 2.77e-24: 112: 9.17
+	Hs
		903208 CUL4A_HUMAN (7-776): 0: 781: 30.41		WDR5_HUMAN (123-437): 8.37e-21: 96.9: 10.98
+	Hs
		1043157 CUL4A_HUMAN (7-776): 0: 781: 30.41		SNR40_HUMAN (149-436): 1.97e-19: 93: 8.03
+	Hs
		1043085 CUL4A_HUMAN (7-776): 0: 781: 30.41		WDR5B_HUMAN (106-437): 1.02e-18: 90.7: 11.01
+	Hs
		903209 CUL4B_HUMAN (7-776): 0: 773: 29.90		WDR5_HUMAN (123-437): 8.37e-21: 96.9: 10.98
+	Hs
		1043297 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBW1B_HUMAN (602-752): 1.09e-16: 86.5: 12.58
+	Hs
		1043509 CUL4B_HUMAN (7-776): 0: 773: 29.90		SNR40_HUMAN (149-436): 1.97e-19: 93: 8.03
+	Hs
		1043441 CUL4B_HUMAN (7-776): 0: 773: 29.90		WDR5B_HUMAN (106-437): 1.02e-18: 90.7: 11.01