HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FXL14 (Q8N1E6)
F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14)
Gene: FBXL14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.930

Property	Details
Experiments	28514442, 33961781, 29103612, 37028429, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 418
+	Mm
		1321914 CUL1_MOUSE (1-776): 0: 912: 99.87		FXL20_MOUSE (7-409): 1.29e-64: 215: 27.32
+	Hs
		1041146 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL20_HUMAN (7-409): 1.18e-64: 215: 27.56
+	Hs
		1041100 CUL1_HUMAN (1-776): 0: 911: 100.00		KDM2B_HUMAN (205-401): 7.04e-32: 130: 20.83
+	Hs
		1041197 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL15_HUMAN (114-379): 2.98e-31: 122: 24.44
+	Hs
		1041256 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL7_HUMAN (201-417): 8.79e-29: 119: 24.35
+	Hs
		1041248 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL17_HUMAN (178-414): 1.46e-22: 102: 18.11
+	Hs
		1041265 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL4_HUMAN (180-391): 3.38e-20: 94.7: 25.89
+	Hs
		1041267 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL2_HUMAN (255-416): 1.88e-20: 94.6: 25.90
+	Hs
		1041049 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL19_HUMAN (176-406): 9.21e-17: 84.3: 20.87
+	Dm
		1097202 CUL1_DROME (4-776): 0: 770: 61.98		Q9VF10_DROME (6-367): 3.96e-61: 212: 23.84
+	At
		137942 CUL1_ARATH (10-776): 0: 722: 30.29		COI1_ARATH (10-415): 2.92e-51: 183: 16.02
+	Hs
		1043217 CUL4A_HUMAN (7-776): 0: 781: 30.41		FXL15_HUMAN (114-379): 2.98e-31: 122: 24.44
+	Hs
		1041552 CUL3_HUMAN (9-776): 0: 748: 30.47		SCRIB_HUMAN (132-417): 5.28e-30: 125: 12.95
+	Hs
		1042760 CUL3_HUMAN (9-776): 0: 748: 30.47		FXL17_HUMAN (178-414): 1.46e-22: 102: 18.11
+	Hs
		1041833 CUL3_HUMAN (9-776): 0: 748: 30.47		FXL19_HUMAN (176-406): 9.21e-17: 84.3: 20.87
+	Hs
		1042879 CUL3_HUMAN (9-776): 0: 748: 30.47		KDM2A_HUMAN (121-386): 1.6e-16: 83.9: 20.68
+	At
		1173680 CUL1_ARATH (10-776): 0: 722: 30.29		EBF2_ARATH (64-304): 7.58e-22: 99.7: 20.33
+	At
		1277334 CUL1_ARATH (10-776): 0: 722: 30.29		SKP2A_ARATH (281-415): 1.02e-18: 88.9: 24.11
+	At
		221522 CUL1_ARATH (10-776): 0: 722: 30.29		SKP2B_ARATH (278-406): 2.67e-13: 72.8: 21.88
+	At
		1123013 CUL1_ARATH (10-776): 0: 722: 30.29		TIR1_ARATH (218-412): 3.14e-10: 63.9: 15.84