HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBXL6 (Q8N531)
F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6) (FBL6A)
Gene: FBXL6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	32576198, 29103612, 37028429
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005737 - cytoplasm GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 539
+	Mm
		1321914 CUL1_MOUSE (1-776): 0: 912: 99.87		FXL20_MOUSE (89-539): 7.58e-65: 219: 19.03
+	Hs
		1041146 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL20_HUMAN (89-539): 5.53e-65: 219: 19.03
+	Mm
		1376707 CUL1_MOUSE (1-776): 0: 912: 99.87		SKP2_MOUSE (68-440): 1.57e-45: 167: 21.35
+	Hs
		1041256 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL7_HUMAN (257-539): 2.73e-25: 110: 16.43
+	Hs
		1041248 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL17_HUMAN (249-538): 4.23e-23: 105: 14.78
+	Hs
		1031190 CUL1_HUMAN (1-776): 0: 911: 100.00		SKP2_HUMAN (107-418): 1.52e-22: 102: 23.29
+	Hs
		1041267 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL2_HUMAN (330-539): 1.25e-19: 93.3: 21.50
+	Hs
		1041088 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL14_HUMAN (348-539): 3.65e-19: 91.7: 19.39
+	Hs
		1041265 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL4_HUMAN (357-537): 1.12e-09: 63: 18.18
+	Hs
		1041197 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL15_HUMAN (136-274): 4.89e-09: 59.9: 22.07
+	At
		1277335 CUL1_ARATH (10-776): 0: 722: 30.29		AFB3_ARATH (115-535): 2.33e-50: 183: 15.90
+	Hs
		1031192 CUL4A_HUMAN (7-776): 0: 781: 30.41		SKP2_HUMAN (107-418): 1.52e-22: 102: 23.29
+	Dm
		1097202 CUL1_DROME (4-776): 0: 770: 61.98		Q9VF10_DROME (124-383): 1.7e-25: 112: 17.74
+	Hs
		1042760 CUL3_HUMAN (9-776): 0: 748: 30.47		FXL17_HUMAN (249-538): 4.23e-23: 105: 14.78
+	At
		1277334 CUL1_ARATH (10-776): 0: 722: 30.29		SKP2A_ARATH (300-513): 1.67e-31: 126: 23.15
+	At
		221522 CUL1_ARATH (10-776): 0: 722: 30.29		SKP2B_ARATH (275-513): 2.18e-29: 121: 21.16
+	Hs
		1043217 CUL4A_HUMAN (7-776): 0: 781: 30.41		FXL15_HUMAN (136-274): 4.89e-09: 59.9: 22.07
+	At
		1173680 CUL1_ARATH (10-776): 0: 722: 30.29		EBF2_ARATH (171-438): 1.89e-21: 99: 15.10
+	At
		1277345 CUL1_ARATH (10-776): 0: 722: 30.29		EBF1_ARATH (121-323): 3.01e-13: 74.5: 14.08
+	At
		1123013 CUL1_ARATH (10-776): 0: 722: 30.29		TIR1_ARATH (371-536): 1.52e-09: 62.6: 16.96