HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: DDX1 (Q92499)
ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB)
Gene: DDX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29395067, 21145461
Identification Methods	proximity labelling technology, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 740
+	Hs
		1043129 CUL4A_HUMAN (7-776): 0: 781: 30.41		DDX1_HUMAN (1-740): 0: 573: 100.00
+	Hs
		1043484 CUL4B_HUMAN (7-776): 0: 773: 29.90		DDX1_HUMAN (1-740): 0: 573: 100.00
+	Hs
		1042169 CUL3_HUMAN (9-776): 0: 748: 30.47		DDX1_HUMAN (1-740): 0: 573: 100.00
+	Hs
		1041414 CUL2_HUMAN (13-776): 0: 720: 35.98		DDX1_HUMAN (1-740): 0: 573: 100.00
+	Hs
		134026 CUL1_HUMAN (1-776): 0: 911: 100.00		DDX3X_HUMAN (1-380): 2.46e-40: 159: 13.47
+	Hs
		1041127 CUL1_HUMAN (1-776): 0: 911: 100.00		DDX17_HUMAN (1-381): 4.07e-36: 147: 12.21
+	Hs
		571441 CUL1_HUMAN (1-776): 0: 911: 100.00		DDX5_HUMAN (1-381): 2.38e-34: 141: 11.96
+	Hs
		757602 CUL1_HUMAN (1-776): 0: 911: 100.00		IF4A3_HUMAN (3-72): 3.92e-11: 67.8: 30.00
+	Hs
		134029 CUL4B_HUMAN (7-776): 0: 773: 29.90		DDX3X_HUMAN (1-380): 2.46e-40: 159: 13.47
+	Hs
		571444 CUL4A_HUMAN (7-776): 0: 781: 30.41		DDX5_HUMAN (1-381): 2.38e-34: 141: 11.96
+	Hs
		1043492 CUL4B_HUMAN (7-776): 0: 773: 29.90		DDX17_HUMAN (1-381): 4.07e-36: 147: 12.21
+	Hs
		571445 CUL4B_HUMAN (7-776): 0: 773: 29.90		DDX5_HUMAN (1-381): 2.38e-34: 141: 11.96
+	Hs
		134028 CUL3_HUMAN (9-776): 0: 748: 30.47		DDX3X_HUMAN (1-380): 2.46e-40: 159: 13.47
+	Hs
		1042199 CUL3_HUMAN (9-776): 0: 748: 30.47		DDX17_HUMAN (1-381): 4.07e-36: 147: 12.21
+	Hs
		571443 CUL3_HUMAN (9-776): 0: 748: 30.47		DDX5_HUMAN (1-381): 2.38e-34: 141: 11.96
+	Mm
		1207268 CUL3_MOUSE (9-776): 0: 747: 30.35		Q8BTS0_MOUSE (1-381): 2.38e-34: 141: 11.96
+	Hs
		134027 CUL2_HUMAN (13-776): 0: 720: 35.98		DDX3X_HUMAN (1-380): 2.46e-40: 159: 13.47
+	Hs
		1041422 CUL2_HUMAN (13-776): 0: 720: 35.98		DDX17_HUMAN (1-381): 4.07e-36: 147: 12.21
+	Hs
		571442 CUL2_HUMAN (13-776): 0: 720: 35.98		DDX5_HUMAN (1-381): 2.38e-34: 141: 11.96
+	Hs
		757603 CUL3_HUMAN (9-776): 0: 748: 30.47		IF4A3_HUMAN (3-72): 3.92e-11: 67.8: 30.00