Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBXW5 (Q969U6)
F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)
Gene: FBXW5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.968

The method score is based on:

Property Details
Experiments 29103612, 37028429, 21145461, 25143387, 25515538, 35813202, 14603323, 23319600, 23314863
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification, coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cullin~F-box-like
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016567 - protein ubiquitination
GO:0019005 - SCF ubiquitin ligase complex
GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
and 1 others

more...

Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 776
Hs

1 566
+ Hs
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024