HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: CSN8 (Q99627)
COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)
Gene: COPS8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	29103612, 18173839, 21145461, 22959436
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 776 Hs			1 209
+	Hs
		1043183 CUL4A_HUMAN (7-776): 0: 781: 30.41		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1043536 CUL4B_HUMAN (7-776): 0: 773: 29.90		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1042368 CUL3_HUMAN (9-776): 0: 748: 30.47		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1041445 CUL2_HUMAN (13-776): 0: 720: 35.98		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	At
		794521 CUL3A_ARATH (7-776): 0: 781: 30.21		CSN8_ARATH (7-209): 9.28e-80: 238: 31.40
+	At
		794514 CUL4_ARATH (6-776): 0: 723: 28.92		CSN8_ARATH (7-209): 9.28e-80: 238: 31.40
+	Hs
		1274027 CUL5_HUMAN (2-776): 0: 622: 28.85		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00