HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: RBX2 (Q9UBF6)
RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)
Gene: RNF7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.953

Property	Details
Experiments	27910872, 27591266, 19250909, 10230407, 11483504, 20638939, 11506706
Identification Methods	affinity chromatography technology, enzymatic study, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cullin~zf-rbx1, Cullin_Nedd8~zf-rbx1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 113
+	Mm
		921509 CUL1_MOUSE (1-776): 0: 912: 99.87		RBX1_MOUSE (18-112): 5.7e-38: 125: 46.94
+	Hs
		921251 CUL1_HUMAN (1-776): 0: 911: 100.00		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Hs
		1041079 CUL1_HUMAN (1-776): 0: 911: 100.00		DZIP3_HUMAN (4-103): 1.17e-23: 96: 20.76
+	Mm
		921499 CUL4A_MOUSE (7-776): 0: 784: 29.77		RBX1_MOUSE (18-112): 5.7e-38: 125: 46.94
+	Hs
		921254 CUL4A_HUMAN (7-776): 0: 781: 30.41		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	At
		1275966 CUL3A_ARATH (7-776): 0: 781: 30.21		RBX1A_ARATH (3-112): 2.07e-36: 121: 42.48
+	Mm
		1111822 CUL4A_MOUSE (7-776): 0: 784: 29.77		RBX2_MOUSE (1-113): 2.07e-33: 114: 96.46
+	Hs
		921255 CUL4B_HUMAN (7-776): 0: 773: 29.90		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Mm
		56790 CUL4B_MOUSE (7-776): 0: 771: 29.90		RBX1_MOUSE (18-112): 5.7e-38: 125: 46.94
+	Hs
		1043275 CUL4A_HUMAN (7-776): 0: 781: 30.41		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Dm
		1097212 CUL1_DROME (4-776): 0: 770: 61.98		RBX1A_DROME (12-112): 9.54e-38: 124: 45.19
+	Dm
		1097197 CUL1_DROME (4-776): 0: 770: 61.98		RBX1B_DROME (12-113): 2.55e-35: 119: 43.27
+	At
		1275962 CUL3B_ARATH (7-776): 0: 768: 29.69		RBX1A_ARATH (3-112): 2.07e-36: 121: 42.48
+	Hs
		1043627 CUL4B_HUMAN (7-776): 0: 773: 29.90		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		921253 CUL3_HUMAN (9-776): 0: 748: 30.47		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Hs
		1043443 CUL4B_HUMAN (7-776): 0: 773: 29.90		DZIP3_HUMAN (4-103): 1.17e-23: 96: 20.76
+	Dm
		1124381 Q5BI50_DROME (7-776): 0: 742: 29.27		RBX1A_DROME (12-112): 9.54e-38: 124: 45.19
+	Hs
		1042735 CUL3_HUMAN (9-776): 0: 748: 30.47		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Sp
		142904 CUL1_SCHPO (1-776): 0: 733: 40.92		RBX1_SCHPO (11-112): 1.09e-35: 119: 40.95
+	Hs
		1042654 CUL3_HUMAN (9-776): 0: 748: 30.47		RNF12_HUMAN (49-104): 2.17e-10: 57.9: 23.21