HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBXL7 (Q9UJT9)
F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7)
Gene: FBXL7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25654763
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 491
+	Hs
		1041088 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL14_HUMAN (111-489): 7.6e-47: 169: 24.74
+	Hs
		1041091 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL6_HUMAN (43-489): 1.82e-45: 168: 20.92
+	Hs
		1041248 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL17_HUMAN (248-488): 1.84e-26: 115: 22.00
+	Hs
		1041265 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL4_HUMAN (257-489): 5.41e-20: 95.1: 19.34
+	Mm
		1321914 CUL1_MOUSE (1-776): 0: 912: 99.87		FXL20_MOUSE (142-352): 4.79e-18: 88.2: 19.63
+	Hs
		1041146 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL20_HUMAN (142-352): 4.83e-18: 88.2: 19.63
+	Hs
		1041267 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL2_HUMAN (137-351): 3.58e-16: 82.4: 20.18
+	Hs
		1041229 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL12_HUMAN (112-347): 1.78e-12: 70.1: 26.86
+	Hs
		1041197 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL15_HUMAN (124-399): 2.11e-11: 66.6: 24.46
+	At
		1123013 CUL1_ARATH (10-776): 0: 722: 30.29		TIR1_ARATH (116-475): 1.16e-48: 178: 17.69
+	At
		1277334 CUL1_ARATH (10-776): 0: 722: 30.29		SKP2A_ARATH (190-484): 2.64e-45: 163: 22.98
+	At
		221522 CUL1_ARATH (10-776): 0: 722: 30.29		SKP2B_ARATH (114-425): 5.5e-45: 162: 19.83
+	Hs
		1042760 CUL3_HUMAN (9-776): 0: 748: 30.47		FXL17_HUMAN (248-488): 1.84e-26: 115: 22.00
+	Dm
		1097202 CUL1_DROME (4-776): 0: 770: 61.98		Q9VF10_DROME (304-490): 6.82e-16: 82.4: 21.18
+	Hs
		1043217 CUL4A_HUMAN (7-776): 0: 781: 30.41		FXL15_HUMAN (124-399): 2.11e-11: 66.6: 24.46
+	At
		1277335 CUL1_ARATH (10-776): 0: 722: 30.29		AFB3_ARATH (21-489): 1.59e-29: 123: 15.54
+	At
		1173680 CUL1_ARATH (10-776): 0: 722: 30.29		EBF2_ARATH (295-490): 1.27e-23: 106: 22.67
+	At
		1277345 CUL1_ARATH (10-776): 0: 722: 30.29		EBF1_ARATH (162-377): 3.4e-19: 92.5: 21.20
+	Hs
		1041495 CUL2_HUMAN (13-776): 0: 720: 35.98		FBXL2_HUMAN (137-351): 3.58e-16: 82.4: 20.18
+	Sc
		624323 CDC53_YEAST (13-776): 0: 628: 31.36		GRR1_YEAST (143-361): 8.83e-21: 98.3: 22.07