HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBX2 (Q9UK22)
F-box only protein 2
Gene: FBXO2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	29103612, 34515398, 21135578, 18203720, 23319600
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 776 Hs			1 296
+	Hs
		1041217 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX6_HUMAN (40-296): 2.4e-133: 381: 49.81
+	Mm
		1193600 CUL1_MOUSE (1-776): 0: 912: 99.87		FBX2_MOUSE (1-296): 2.13e-131: 376: 83.00
+	Hs
		1041202 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX44_HUMAN (43-296): 1.71e-125: 360: 48.82
+	Hs
		1041142 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX17_HUMAN (47-294): 5.27e-103: 303: 38.43
+	Hs
		1041102 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX27_HUMAN (60-294): 1e-96: 288: 40.39
+	Hs
		1043220 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBX44_HUMAN (43-296): 1.71e-125: 360: 48.82
+	Hs
		1043585 CUL4B_HUMAN (7-776): 0: 773: 29.90		FBX44_HUMAN (43-296): 1.71e-125: 360: 48.82
+	Hs
		1274013 CUL5_HUMAN (2-776): 0: 622: 28.85		FBX17_HUMAN (47-294): 5.27e-103: 303: 38.43