HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBXL4 (Q9UKA2)
F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5)
Gene: FBXL4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	32877691, 36896912, 37028429
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 621
+	Hs
		1041146 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL20_HUMAN (282-619): 3.92e-59: 206: 23.74
+	Mm
		1321914 CUL1_MOUSE (1-776): 0: 912: 99.87		FXL20_MOUSE (282-619): 5.87e-59: 205: 23.49
+	Hs
		1041256 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL7_HUMAN (245-586): 1.31e-36: 145: 21.55
+	Hs
		1041088 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL14_HUMAN (220-541): 9.42e-32: 129: 19.89
+	Hs
		1041100 CUL1_HUMAN (1-776): 0: 911: 100.00		KDM2B_HUMAN (404-621): 1.48e-26: 117: 19.49
+	Hs
		1041197 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL15_HUMAN (273-522): 6.94e-28: 115: 23.05
+	Hs
		1041248 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL17_HUMAN (181-508): 2.12e-17: 88.2: 17.20
+	Hs
		1041267 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL2_HUMAN (121-437): 7.52e-15: 78.9: 13.78
+	Dm
		1097202 CUL1_DROME (4-776): 0: 770: 61.98		Q9VF10_DROME (279-616): 7.54e-59: 212: 19.63
+	Hs
		1031190 CUL1_HUMAN (1-776): 0: 911: 100.00		SKP2_HUMAN (482-613): 1.36e-11: 69: 15.67
+	Mm
		1376707 CUL1_MOUSE (1-776): 0: 912: 99.87		SKP2_MOUSE (433-612): 2.23e-10: 65.1: 19.40
+	Hs
		1041091 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL6_HUMAN (500-615): 9.42e-09: 60.1: 19.83
+	Hs
		1043217 CUL4A_HUMAN (7-776): 0: 781: 30.41		FXL15_HUMAN (273-522): 6.94e-28: 115: 23.05
+	At
		1277334 CUL1_ARATH (10-776): 0: 722: 30.29		SKP2A_ARATH (428-621): 3.19e-35: 138: 25.38
+	At
		221522 CUL1_ARATH (10-776): 0: 722: 30.29		SKP2B_ARATH (425-621): 4.51e-34: 135: 25.50
+	Hs
		1031192 CUL4A_HUMAN (7-776): 0: 781: 30.41		SKP2_HUMAN (482-613): 1.36e-11: 69: 15.67
+	At
		1173680 CUL1_ARATH (10-776): 0: 722: 30.29		EBF2_ARATH (296-584): 2.36e-27: 119: 19.73
+	At
		1123013 CUL1_ARATH (10-776): 0: 722: 30.29		TIR1_ARATH (208-617): 3.16e-26: 115: 14.89
+	Hs
		1042760 CUL3_HUMAN (9-776): 0: 748: 30.47		FXL17_HUMAN (181-508): 2.12e-17: 88.2: 17.20
+	At
		1277335 CUL1_ARATH (10-776): 0: 722: 30.29		AFB3_ARATH (208-617): 2.83e-25: 112: 16.44