HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBXL2 (Q9UKC9)
F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3)
Gene: FBXL2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.956

Property	Details
Experiments	29103612, 37028429, 26790640, 28614300, 34635651, 36662618, 22399757
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005737 - cytoplasm GO:0006513 - protein monoubiquitination GO:0016567 - protein ubiquitination GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 423
+	Mm
		1321914 CUL1_MOUSE (1-776): 0: 912: 99.87		FXL20_MOUSE (2-423): 5.25e-88: 275: 77.96
+	Hs
		1041146 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL20_HUMAN (2-423): 4.92e-88: 275: 78.20
+	Hs
		1041256 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL7_HUMAN (1-367): 1.14e-59: 203: 27.49
+	Hs
		1041088 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL14_HUMAN (9-421): 2.79e-53: 185: 28.67
+	Hs
		1041265 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL4_HUMAN (132-422): 1.16e-28: 120: 20.72
+	Hs
		1041091 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL6_HUMAN (180-406): 3.34e-19: 91.6: 20.09
+	Hs
		1041248 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL17_HUMAN (144-423): 8.14e-18: 87.6: 17.50
+	Mm
		1376707 CUL1_MOUSE (1-776): 0: 912: 99.87		SKP2_MOUSE (211-418): 1.06e-12: 71.2: 21.05
+	Hs
		1031190 CUL1_HUMAN (1-776): 0: 911: 100.00		SKP2_HUMAN (235-409): 1.36e-09: 61.6: 20.50
+	Hs
		1041197 CUL1_HUMAN (1-776): 0: 911: 100.00		FXL15_HUMAN (80-229): 7.55e-09: 58.5: 23.84
+	Dm
		1097202 CUL1_DROME (4-776): 0: 770: 61.98		Q9VF10_DROME (9-352): 2.15e-50: 183: 28.90
+	At
		1123013 CUL1_ARATH (10-776): 0: 722: 30.29		TIR1_ARATH (14-422): 1.37e-34: 137: 20.05
+	At
		1277335 CUL1_ARATH (10-776): 0: 722: 30.29		AFB3_ARATH (15-419): 5.05e-32: 129: 17.49
+	Hs
		1031192 CUL4A_HUMAN (7-776): 0: 781: 30.41		SKP2_HUMAN (235-409): 1.36e-09: 61.6: 20.50
+	Hs
		1043217 CUL4A_HUMAN (7-776): 0: 781: 30.41		FXL15_HUMAN (80-229): 7.55e-09: 58.5: 23.84
+	At
		1173680 CUL1_ARATH (10-776): 0: 722: 30.29		EBF2_ARATH (19-362): 2.18e-27: 116: 23.36
+	At
		1277334 CUL1_ARATH (10-776): 0: 722: 30.29		SKP2A_ARATH (236-422): 9.51e-28: 114: 27.23
+	Hs
		1042760 CUL3_HUMAN (9-776): 0: 748: 30.47		FXL17_HUMAN (144-423): 8.14e-18: 87.6: 17.50
+	Hs
		1042318 CUL3_HUMAN (9-776): 0: 748: 30.47		LRRC7_HUMAN (12-242): 1.96e-17: 86.9: 12.05
+	At
		221522 CUL1_ARATH (10-776): 0: 722: 30.29		SKP2B_ARATH (235-416): 2.08e-25: 108: 26.34