HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	31444342, 21145461, 16503656, 18274552
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cullin~ubiquitin, Cullin_Nedd8~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 81
+	Hs
		923984 CUL4A_HUMAN (4-745): 0: 773: 26.86		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		923985 CUL4B_HUMAN (4-745): 0: 771: 27.79		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		923983 CUL3_HUMAN (1-745): 0: 768: 26.38		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		924296 CUL4A_HUMAN (4-745): 0: 773: 26.86		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	At
		1352191 CUL3A_ARATH (3-745): 0: 788: 30.07		RUB1_ARATH (3-76): 7.75e-26: 94.5: 85.14
+	Hs
		1041004 CUL1_HUMAN (6-745): 0: 775: 36.24		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		475024 CUL4B_HUMAN (4-745): 0: 771: 27.79		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		1043010 CUL4A_HUMAN (4-745): 0: 773: 26.86		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		1043371 CUL4B_HUMAN (4-745): 0: 771: 27.79		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		1041658 CUL3_HUMAN (1-745): 0: 768: 26.38		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	At
		1321116 CUL3B_ARATH (3-745): 0: 774: 30.07		RUB1_ARATH (3-76): 7.75e-26: 94.5: 85.14
+	Dm
		1213846 Q8IP45_DROME (2-745): 0: 734: 27.70		NEDD8_DROME (1-76): 2.21e-34: 113: 93.42
+	Dm
		1097203 CUL1_DROME (6-745): 0: 726: 33.25		NEDD8_DROME (1-76): 2.21e-34: 113: 93.42
+	At
		1277343 CUL1_ARATH (3-745): 0: 727: 26.53		RUB1_ARATH (3-76): 7.75e-26: 94.5: 85.14
+	At
		1247030 CUL1_ARATH (3-745): 0: 727: 26.53		RUB2_ARATH (3-76): 1.03e-24: 91.8: 85.14
+	Sp
		142907 CUL1_SCHPO (1-745): 0: 712: 30.89		UBL1_SCHPO (1-76): 9.64e-30: 102: 81.58
+	Ce
		1088883 CUL3_CAEEL (1-745): 0: 683: 26.03		NEDD8_CAEEL (1-77): 7.56e-34: 112: 87.01
+	Hs
		1079566 CUL5_HUMAN (7-745): 0: 627: 26.69		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Sp
		145590 CUL3_SCHPO (8-745): 0: 620: 23.84		UBL1_SCHPO (1-76): 9.64e-30: 102: 81.58
+	Sc
		977843 CDC53_YEAST (5-745): 0: 622: 25.94		RUB1_YEAST (1-76): 1.45e-21: 81.3: 59.21