HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: CSN6 (Q7L5N1)
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
Gene: COPS6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.949

Property	Details
Experiments	33961781, 21145461, 26186194, 28514442, 19615732, 19295130
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin_Nedd8~JAB
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 327
+	Hs
		1041064 CUL1_HUMAN (6-745): 0: 775: 36.24		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1043079 CUL4A_HUMAN (4-745): 0: 773: 26.86		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1043429 CUL4B_HUMAN (4-745): 0: 771: 27.79		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1041897 CUL3_HUMAN (1-745): 0: 768: 26.38		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		91398 CUL4B_HUMAN (4-745): 0: 771: 27.79		E7EM64_HUMAN (1-327): 1.07e-139: 399: 99.69
+	Hs
		124855 CUL3_HUMAN (1-745): 0: 768: 26.38		EIF3F_HUMAN (10-306): 1.15e-110: 327: 22.07
+	Hs
		849195 CUL3_HUMAN (1-745): 0: 768: 26.38		PSMD7_HUMAN (37-317): 1.48e-97: 292: 24.48
+	Hs
		1184935 CUL5_HUMAN (7-745): 0: 627: 26.69		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		177020 CUL4A_HUMAN (4-745): 0: 773: 26.86		EIF3H_HUMAN (33-305): 9.03e-59: 194: 14.38
+	Ce
		954204 CUL3_CAEEL (1-745): 0: 683: 26.03		CSN5_CAEEL (29-253): 1.44e-51: 176: 11.95