HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: LLR1 (Q96L50)
Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5)
Gene: LRR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	33961781, 21145461, 15601820, 19295130
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 414
+	Hs
		1043165 CUL4A_HUMAN (4-745): 0: 773: 26.86		LLR1_HUMAN (1-414): 3.84e-63: 210: 100.00
+	Hs
		1042302 CUL3_HUMAN (1-745): 0: 768: 26.38		LLR1_HUMAN (1-414): 3.84e-63: 210: 100.00
+	Hs
		1042318 CUL3_HUMAN (1-745): 0: 768: 26.38		LRRC7_HUMAN (37-414): 8.64e-52: 188: 18.64
+	Hs
		1023157 CUL3_HUMAN (1-745): 0: 768: 26.38		FLII_HUMAN (94-331): 1.96e-40: 155: 19.70
+	Ce
		1088869 CUL2_CAEEL (2-745): 0: 720: 42.27		Q19988_CAEEL (1-305): 4.24e-56: 192: 25.16
+	Hs
		1042425 CUL3_HUMAN (1-745): 0: 768: 26.38		LRRC1_HUMAN (114-306): 1.09e-32: 130: 26.15
+	Hs
		1041552 CUL3_HUMAN (1-745): 0: 768: 26.38		SCRIB_HUMAN (177-414): 1.35e-30: 126: 20.75
+	Hs
		1043528 CUL4B_HUMAN (4-745): 0: 771: 27.79		ERBIN_HUMAN (1-237): 8.42e-25: 109: 16.18
+	Hs
		1042341 CUL3_HUMAN (1-745): 0: 768: 26.38		ERBIN_HUMAN (1-237): 8.42e-25: 109: 16.18
+	Hs
		1043003 CUL4A_HUMAN (4-745): 0: 773: 26.86		RSU1_HUMAN (204-308): 1.26e-16: 81.2: 29.25
+	Hs
		1041636 CUL3_HUMAN (1-745): 0: 768: 26.38		RSU1_HUMAN (204-308): 1.26e-16: 81.2: 29.25
+	Hs
		1041832 CUL3_HUMAN (1-745): 0: 768: 26.38		LRC8B_HUMAN (166-410): 2.08e-13: 74.2: 20.45
+	Hs
		1274018 CUL5_HUMAN (7-745): 0: 627: 26.69		LLR1_HUMAN (1-414): 3.84e-63: 210: 100.00
+	Hs
		1274011 CUL5_HUMAN (7-745): 0: 627: 26.69		LRC58_HUMAN (86-238): 1.41e-20: 94.3: 19.23