HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: CSN8 (Q99627)
COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)
Gene: COPS8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.704

Property	Details
Experiments	28514442, 27173435, 33961781, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 209
+	Hs
		1041162 CUL1_HUMAN (6-745): 0: 775: 36.24		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1043183 CUL4A_HUMAN (4-745): 0: 773: 26.86		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1043536 CUL4B_HUMAN (4-745): 0: 771: 27.79		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1042368 CUL3_HUMAN (1-745): 0: 768: 26.38		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	At
		794521 CUL3A_ARATH (3-745): 0: 788: 30.07		CSN8_ARATH (7-209): 9.28e-80: 238: 31.40
+	At
		794514 CUL4_ARATH (4-745): 0: 720: 26.60		CSN8_ARATH (7-209): 9.28e-80: 238: 31.40
+	Hs
		1274027 CUL5_HUMAN (7-745): 0: 627: 26.69		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00