HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: RBX2 (Q9UBF6)
RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)
Gene: RNF7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	19250909, 10230407
Identification Methods	enzymatic study, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cullin~zf-rbx1, Cullin_Nedd8~zf-rbx1
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 113
+	Hs
		921252 CUL2_HUMAN (1-745): 0: 840: 100.00		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	At
		1275966 CUL3A_ARATH (3-745): 0: 788: 30.07		RBX1A_ARATH (3-112): 2.07e-36: 121: 42.48
+	Hs
		921251 CUL1_HUMAN (6-745): 0: 775: 36.24		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Mm
		921509 CUL1_MOUSE (6-745): 0: 775: 36.24		RBX1_MOUSE (18-112): 5.7e-38: 125: 46.94
+	Mm
		921499 CUL4A_MOUSE (4-745): 0: 774: 26.73		RBX1_MOUSE (18-112): 5.7e-38: 125: 46.94
+	Hs
		921254 CUL4A_HUMAN (4-745): 0: 773: 26.86		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Mm
		56790 CUL4B_MOUSE (4-745): 0: 771: 27.79		RBX1_MOUSE (18-112): 5.7e-38: 125: 46.94
+	Hs
		921255 CUL4B_HUMAN (4-745): 0: 771: 27.79		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	At
		1275962 CUL3B_ARATH (3-745): 0: 774: 30.07		RBX1A_ARATH (3-112): 2.07e-36: 121: 42.48
+	Hs
		921253 CUL3_HUMAN (1-745): 0: 768: 26.38		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Hs
		1041242 CUL1_HUMAN (6-745): 0: 775: 36.24		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Mm
		1111822 CUL4A_MOUSE (4-745): 0: 774: 26.73		RBX2_MOUSE (1-113): 2.07e-33: 114: 96.46
+	Hs
		1043275 CUL4A_HUMAN (4-745): 0: 773: 26.86		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		1043627 CUL4B_HUMAN (4-745): 0: 771: 27.79		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		1042735 CUL3_HUMAN (1-745): 0: 768: 26.38		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		1041079 CUL1_HUMAN (6-745): 0: 775: 36.24		DZIP3_HUMAN (4-103): 1.17e-23: 96: 20.76
+	Hs
		1043443 CUL4B_HUMAN (4-745): 0: 771: 27.79		DZIP3_HUMAN (4-103): 1.17e-23: 96: 20.76
+	Dm
		1124381 Q5BI50_DROME (4-745): 0: 742: 27.06		RBX1A_DROME (12-112): 9.54e-38: 124: 45.19
+	Dm
		1213836 Q8IP45_DROME (2-745): 0: 734: 27.70		RBX1B_DROME (12-113): 2.55e-35: 119: 43.27
+	Hs
		1042654 CUL3_HUMAN (1-745): 0: 768: 26.38		RNF12_HUMAN (49-104): 2.17e-10: 57.9: 23.21