HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: CSN7A (Q9UBW8)
COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a)
Gene: COPS7A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	21145461, 26496610, 19295130
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 275
+	Hs
		1041468 CUL2_HUMAN (1-745): 0: 840: 100.00		CSN7B_HUMAN (1-267): 2.01e-87: 262: 57.68
+	Hs
		1041247 CUL1_HUMAN (6-745): 0: 775: 36.24		CSN7A_HUMAN (1-275): 4.23e-101: 298: 100.00
+	Hs
		1043276 CUL4A_HUMAN (4-745): 0: 773: 26.86		CSN7A_HUMAN (1-275): 4.23e-101: 298: 100.00
+	Hs
		1043630 CUL4B_HUMAN (4-745): 0: 771: 27.79		CSN7A_HUMAN (1-275): 4.23e-101: 298: 100.00
+	Hs
		1042750 CUL3_HUMAN (1-745): 0: 768: 26.38		CSN7A_HUMAN (1-275): 4.23e-101: 298: 100.00
+	Hs
		1041205 CUL1_HUMAN (6-745): 0: 775: 36.24		CSN7B_HUMAN (1-267): 2.01e-87: 262: 57.68
+	Hs
		1043232 CUL4A_HUMAN (4-745): 0: 773: 26.86		CSN7B_HUMAN (1-267): 2.01e-87: 262: 57.68
+	Hs
		1043598 CUL4B_HUMAN (4-745): 0: 771: 27.79		CSN7B_HUMAN (1-267): 2.01e-87: 262: 57.68
+	Hs
		1042568 CUL3_HUMAN (1-745): 0: 768: 26.38		CSN7B_HUMAN (1-267): 2.01e-87: 262: 57.68
+	Hs
		1274073 CUL5_HUMAN (7-745): 0: 627: 26.69		CSN7A_HUMAN (1-275): 4.23e-101: 298: 100.00
+	Hs
		1274053 CUL5_HUMAN (7-745): 0: 627: 26.69		CSN7B_HUMAN (1-267): 2.01e-87: 262: 57.68
+	Ce
		1088884 CUL3_CAEEL (1-745): 0: 683: 26.03		EIF3M_CAEEL (1-198): 1.15e-48: 167: 17.96