HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KCD21 (Q4G0X4)
BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21)
Gene: KCTD21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 260
+	Hs
		1042523 CUL3_HUMAN (1-768): 0: 951: 100.00		BACD3_HUMAN (2-227): 4.85e-66: 209: 28.99
+	Hs
		1042165 CUL3_HUMAN (1-768): 0: 951: 100.00		BACD1_HUMAN (2-229): 7.91e-63: 201: 27.39
+	Hs
		1041533 CUL3_HUMAN (1-768): 0: 951: 100.00		BACD2_HUMAN (3-230): 1.46e-61: 197: 26.97
+	Hs
		1041790 CUL3_HUMAN (1-768): 0: 951: 100.00		KCD11_HUMAN (28-259): 4.45e-62: 196: 37.66
+	Hs
		1041891 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD9_HUMAN (3-220): 5.5e-46: 159: 25.32
+	Hs
		1042096 CUL3_HUMAN (1-768): 0: 951: 100.00		SHKB1_HUMAN (3-131): 1.25e-37: 141: 41.09
+	Hs
		1042934 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD3_HUMAN (3-130): 1.87e-37: 141: 35.16
+	Hs
		1042675 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD5_HUMAN (1-109): 2.66e-40: 140: 32.43
+	Hs
		1042035 CUL3_HUMAN (1-768): 0: 951: 100.00		KCD17_HUMAN (3-109): 3.4e-38: 137: 36.11
+	Hs
		1042063 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD6_HUMAN (1-101): 5.28e-39: 137: 69.31
+	Hs
		1042309 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD7_HUMAN (2-112): 2.74e-38: 137: 38.74
+	Hs
		1041584 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD2_HUMAN (4-109): 3.36e-38: 136: 31.19
+	Hs
		1042242 CUL3_HUMAN (1-768): 0: 951: 100.00		KCD12_HUMAN (2-96): 3.77e-37: 135: 45.36
+	Hs
		1041881 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD1_HUMAN (4-107): 1.58e-37: 134: 45.71
+	Hs
		1041839 CUL3_HUMAN (1-768): 0: 951: 100.00		KCD18_HUMAN (3-89): 1.62e-18: 85.9: 44.83
+	Ce
		1088879 CUL3_CAEEL (4-768): 0: 792: 48.08		Q18986_CAEEL (2-234): 8.81e-50: 165: 23.11
+	Ce
		954547 CUL3_CAEEL (4-768): 0: 792: 48.08		P91563_CAEEL (1-233): 1.63e-49: 164: 22.32
+	Ce
		184054 CUL3_CAEEL (4-768): 0: 792: 48.08		O16612_CAEEL (5-178): 1.66e-41: 142: 18.97
+	Ce
		109385 CUL3_CAEEL (4-768): 0: 792: 48.08		H2KY83_CAEEL (5-139): 9.31e-39: 135: 23.36
+	Ce
		1088887 CUL3_CAEEL (4-768): 0: 792: 48.08		Q965M5_CAEEL (2-128): 5.03e-37: 131: 31.06