HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.988

Property	Details
Experiments	27716508, 29999490, 30190310, 18303015, 35120648, 36652337, 25416956, 32296183, 34878901, 35563538, 16547521, 17543862, 21145461, 19295130, unassigned1304, 34591642
Identification Methods	affinity chromatography technology, two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid, tandem affinity purification, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005829 - cytosol GO:0006513 - protein monoubiquitination GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport GO:0016055 - Wnt signaling pathway GO:0031463 - Cul3-RING ubiquitin ligase complex and 1 others more... GO:0048208 - COPII vesicle coating
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 568
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH17_HUMAN (11-566): 1.87e-162: 479: 40.40
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (11-566): 1.56e-162: 479: 40.75
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (8-564): 2.73e-161: 475: 35.88
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (5-565): 1.58e-159: 469: 39.79
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL2_HUMAN (13-567): 3.8e-158: 466: 41.36
+	Hs
		1042720 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL8_HUMAN (5-565): 5.61e-156: 461: 37.41
+	Hs
		1041986 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL7_HUMAN (19-563): 2.02e-155: 459: 32.19
+	Hs
		1042674 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH28_HUMAN (15-565): 1.89e-155: 458: 37.77
+	Hs
		1042167 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL6_HUMAN (21-542): 7.38e-83: 272: 31.90
+	Hs
		1042026 CUL3_HUMAN (1-768): 0: 951: 100.00		Q8N4I8_HUMAN (15-276): 3.42e-82: 260: 46.77
+	Hs
		1042324 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL5_HUMAN (360-567): 3.93e-59: 211: 36.54
+	Hs
		1042624 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL1_HUMAN (365-567): 7.55e-59: 210: 37.93
+	Hs
		1042489 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL4_HUMAN (360-567): 9.8e-58: 207: 36.54
+	Hs
		1042722 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL9_HUMAN (380-568): 3.91e-43: 164: 27.55
+	Hs
		1042027 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH36_HUMAN (379-567): 1.6e-35: 143: 25.63
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (428-568): 1.65e-33: 136: 33.80
+	Hs
		152489 CUL3_HUMAN (1-768): 0: 951: 100.00		ENC1_HUMAN (378-568): 9.99e-32: 131: 21.29
+	Hs
		1041718 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH26_HUMAN (365-568): 5.54e-30: 126: 23.26
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH24_HUMAN (394-568): 1.15e-28: 122: 29.67
+	Hs
		1042508 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH25_HUMAN (471-567): 4.6e-11: 67.5: 16.33