HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: HECD3 (Q5T447)
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)
Gene: HECTD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016567 - protein ubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 861
+	Hs
		1042286 CUL3_HUMAN (1-768): 0: 951: 100.00		ITCH_HUMAN (318-855): 0: 545: 17.83
+	Hs
		1041922 CUL3_HUMAN (1-768): 0: 951: 100.00		HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78
+	Hs
		1043434 CUL4B_HUMAN (5-768): 0: 779: 36.77		HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78
+	Hs
		808117 CUL1_HUMAN (18-768): 0: 707: 30.57		NEDD4_HUMAN (322-853): 5.8e-176: 545: 18.46
+	Hs
		125440 CUL1_HUMAN (18-768): 0: 707: 30.57		WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74
+	Hs
		1041654 CUL3_HUMAN (1-768): 0: 951: 100.00		HERC1_HUMAN (517-855): 3.98e-53: 204: 36.72
+	Hs
		808209 CUL5_HUMAN (25-768): 0: 597: 23.77		NEDD4_HUMAN (322-853): 5.8e-176: 545: 18.46
+	Hs
		1041632 CUL3_HUMAN (1-768): 0: 951: 100.00		UBE3C_HUMAN (495-845): 2.66e-20: 99: 27.64
+	Hs
		1041983 CUL3_HUMAN (1-768): 0: 951: 100.00		CUL9_HUMAN (245-370): 1.19e-18: 94: 40.63
+	Hs
		1041597 CUL3_HUMAN (1-768): 0: 951: 100.00		CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63
+	Hs
		195697 CUL3_HUMAN (1-768): 0: 951: 100.00		ZZEF1_HUMAN (233-369): 8.7e-18: 91.3: 34.06
+	Hs
		1043362 CUL4B_HUMAN (5-768): 0: 779: 36.77		UBE3C_HUMAN (495-845): 2.66e-20: 99: 27.64
+	Hs
		1040987 CUL1_HUMAN (18-768): 0: 707: 30.57		CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63