HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KCD11 (Q693B1)
BTB/POZ domain-containing protein KCTD11 (KCASH1 protein) (Potassium channel tetramerization domain-containing protein 11) (RING-type E3 ubiquitin transferase subunit KCTD11)
Gene: KCTD11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	25974686, 20081843, 21237243
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 232
+	Hs
		1041705 CUL3_HUMAN (1-768): 0: 951: 100.00		KCD21_HUMAN (1-232): 3.99e-78: 237: 38.08
+	Hs
		1042675 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD5_HUMAN (9-174): 1.06e-50: 166: 16.27
+	Hs
		1041584 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD2_HUMAN (9-174): 3.09e-48: 161: 17.47
+	Hs
		1041881 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD1_HUMAN (2-214): 5.33e-46: 155: 21.60
+	Hs
		1042035 CUL3_HUMAN (1-768): 0: 951: 100.00		KCD17_HUMAN (13-165): 2.01e-43: 150: 19.61
+	Hs
		1042523 CUL3_HUMAN (1-768): 0: 951: 100.00		BACD3_HUMAN (1-141): 4.02e-39: 139: 25.49
+	Hs
		1042165 CUL3_HUMAN (1-768): 0: 951: 100.00		BACD1_HUMAN (1-142): 4.88e-36: 131: 25.81
+	Hs
		1041533 CUL3_HUMAN (1-768): 0: 951: 100.00		BACD2_HUMAN (1-141): 4.19e-35: 128: 24.68
+	Hs
		1042242 CUL3_HUMAN (1-768): 0: 951: 100.00		KCD12_HUMAN (1-121): 5.57e-28: 109: 24.79
+	Hs
		1042063 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD6_HUMAN (1-78): 2.69e-27: 106: 50.00
+	Hs
		1041839 CUL3_HUMAN (1-768): 0: 951: 100.00		KCD18_HUMAN (1-142): 5.6e-25: 103: 20.00
+	Hs
		1041891 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD9_HUMAN (1-139): 5.16e-25: 102: 18.71
+	Hs
		1042309 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD7_HUMAN (1-90): 6.92e-24: 98.4: 36.67
+	Dm
		1213854 Q8IP45_DROME (17-768): 0: 868: 69.08		Q9W579_DROME (9-174): 1.15e-37: 132: 19.28
+	Ce
		1088879 CUL3_CAEEL (4-768): 0: 792: 48.08		Q18986_CAEEL (1-207): 9.28e-46: 154: 24.11
+	Ce
		184054 CUL3_CAEEL (4-768): 0: 792: 48.08		O16612_CAEEL (5-160): 3.76e-38: 133: 15.39
+	Ce
		954547 CUL3_CAEEL (4-768): 0: 792: 48.08		P91563_CAEEL (6-171): 3.73e-37: 131: 19.66
+	Ce
		109385 CUL3_CAEEL (4-768): 0: 792: 48.08		H2KY83_CAEEL (5-156): 1.21e-36: 128: 18.42
+	Ce
		1088878 CUL3_CAEEL (4-768): 0: 792: 48.08		Q18776_CAEEL (9-149): 4e-33: 122: 18.31
+	Ce
		1088887 CUL3_CAEEL (4-768): 0: 792: 48.08		Q965M5_CAEEL (4-150): 1.34e-29: 111: 21.57