HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: ASCC3 (Q8N3C0)
Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200)
Gene: ASCC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 2202
+	Hs
		272128 CUL3_HUMAN (1-768): 0: 951: 100.00		U520_HUMAN (7-2198): 0: 1584: 37.61
+	Hs
		272129 CUL4A_HUMAN (10-768): 0: 791: 38.32		U520_HUMAN (7-2198): 0: 1584: 37.61
+	Hs
		272127 CUL2_HUMAN (30-768): 0: 672: 26.17		U520_HUMAN (7-2198): 0: 1584: 37.61
+	Hs
		1042199 CUL3_HUMAN (1-768): 0: 951: 100.00		DDX17_HUMAN (407-898): 4.34e-100: 342: 12.97
+	Hs
		571443 CUL3_HUMAN (1-768): 0: 951: 100.00		DDX5_HUMAN (1248-1735): 2.96e-100: 338: 11.38
+	Mm
		1207268 CUL3_MOUSE (1-768): 0: 949: 99.48		Q8BTS0_MOUSE (1248-1735): 4.41e-100: 338: 11.38
+	Hs
		786944 CUL3_HUMAN (1-768): 0: 951: 100.00		MTREX_HUMAN (366-1187): 1.53e-88: 316: 15.84
+	Hs
		134028 CUL3_HUMAN (1-768): 0: 951: 100.00		DDX3X_HUMAN (1252-1734): 3.79e-90: 311: 12.50
+	Hs
		571444 CUL4A_HUMAN (10-768): 0: 791: 38.32		DDX5_HUMAN (1248-1735): 2.96e-100: 338: 11.38
+	Hs
		1043492 CUL4B_HUMAN (5-768): 0: 779: 36.77		DDX17_HUMAN (407-898): 4.34e-100: 342: 12.97
+	Hs
		571445 CUL4B_HUMAN (5-768): 0: 779: 36.77		DDX5_HUMAN (1248-1735): 2.96e-100: 338: 11.38
+	Hs
		134029 CUL4B_HUMAN (5-768): 0: 779: 36.77		DDX3X_HUMAN (1252-1734): 3.79e-90: 311: 12.50
+	Hs
		1041127 CUL1_HUMAN (18-768): 0: 707: 30.57		DDX17_HUMAN (407-898): 4.34e-100: 342: 12.97
+	Hs
		571441 CUL1_HUMAN (18-768): 0: 707: 30.57		DDX5_HUMAN (1248-1735): 2.96e-100: 338: 11.38
+	Hs
		786943 CUL1_HUMAN (18-768): 0: 707: 30.57		MTREX_HUMAN (366-1187): 1.53e-88: 316: 15.84
+	Hs
		134026 CUL1_HUMAN (18-768): 0: 707: 30.57		DDX3X_HUMAN (1252-1734): 3.79e-90: 311: 12.50
+	Hs
		1041422 CUL2_HUMAN (30-768): 0: 672: 26.17		DDX17_HUMAN (407-898): 4.34e-100: 342: 12.97
+	Hs
		571442 CUL2_HUMAN (30-768): 0: 672: 26.17		DDX5_HUMAN (1248-1735): 2.96e-100: 338: 11.38
+	Hs
		134027 CUL2_HUMAN (30-768): 0: 672: 26.17		DDX3X_HUMAN (1252-1734): 3.79e-90: 311: 12.50
+	Hs
		134152 CUL5_HUMAN (25-768): 0: 597: 23.77		DDX3X_HUMAN (1252-1734): 3.79e-90: 311: 12.50