HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: LZTR1 (Q8N653)
Leucine-zipper-like transcriptional regulator 1 (LZTR-1)
Gene: LZTR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	30442762, 30481304, 30872527, 34878901, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BTB~Cullin
Common GO terms	GO:0005794 - Golgi apparatus GO:0016567 - protein ubiquitination GO:0031463 - Cul3-RING ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 840
+	Hs
		1042716 CUL3_HUMAN (1-768): 0: 951: 100.00		IBTK_HUMAN (419-820): 2.71e-71: 258: 17.23
+	Hs
		214258 CUL3_HUMAN (1-768): 0: 951: 100.00		SPOP_HUMAN (662-837): 6.69e-62: 215: 31.29
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (650-837): 9.12e-47: 179: 21.16
+	Hs
		848213 CUL3_HUMAN (1-768): 0: 951: 100.00		HCFC1_HUMAN (104-467): 7.65e-45: 177: 17.16
+	Hs
		1042324 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL5_HUMAN (4-237): 5.73e-40: 160: 20.94
+	Hs
		1042624 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL1_HUMAN (238-525): 1.38e-39: 159: 13.75
+	Hs
		1042674 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH28_HUMAN (224-524): 1.62e-35: 144: 14.11
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (224-452): 6.99e-34: 139: 13.81
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (218-456): 1.7e-31: 133: 13.75
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (236-481): 2.95e-30: 129: 13.44
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH12_HUMAN (1-186): 2.59e-28: 122: 18.82
+	Hs
		1042964 CUL3_HUMAN (1-768): 0: 951: 100.00		NS1BP_HUMAN (2-164): 5.28e-24: 109: 15.95
+	Hs
		1042720 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL8_HUMAN (294-525): 3.35e-21: 100: 12.02
+	Hs
		1042722 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL9_HUMAN (295-525): 1.35e-16: 86.2: 12.13
+	Hs
		1042727 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH13_HUMAN (295-525): 1.99e-16: 85.8: 12.13
+	Hs
		1042489 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL4_HUMAN (5-127): 8.72e-16: 83.9: 18.70
+	Hs
		1042070 CUL3_HUMAN (1-768): 0: 951: 100.00		RCBT1_HUMAN (665-821): 1.6e-15: 82.4: 28.66
+	Hs
		1042881 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH20_HUMAN (346-525): 1.26e-12: 73.5: 12.16
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH17_HUMAN (324-525): 7.51e-11: 67.7: 10.84
+	Hs
		1042768 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL3_HUMAN (324-575): 1.65e-09: 63.4: 10.67