HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KBTB8 (Q8NFY9)
Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP)
Gene: KBTBD8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	26399832, 29999490, 30190310, 34878901, 35563538, 21145461
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0006513 - protein monoubiquitination GO:0031463 - Cul3-RING ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 601
+	Hs
		1042149 CUL3_HUMAN (1-768): 0: 951: 100.00		KBTB7_HUMAN (10-598): 1.43e-161: 479: 27.66
+	Hs
		1041942 CUL3_HUMAN (1-768): 0: 951: 100.00		KBTB6_HUMAN (11-598): 3.2e-159: 473: 27.39
+	Hs
		238083 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH41_HUMAN (17-592): 4.32e-160: 473: 24.84
+	Hs
		1041718 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH26_HUMAN (10-588): 1.15e-142: 428: 22.31
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (1-586): 2.25e-139: 420: 21.23
+	Hs
		1041715 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH22_HUMAN (1-599): 2.68e-131: 400: 22.12
+	Hs
		1042027 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH36_HUMAN (8-588): 5.07e-125: 383: 21.15
+	Hs
		1041991 CUL3_HUMAN (1-768): 0: 951: 100.00		KBTB2_HUMAN (20-599): 1.47e-122: 377: 32.40
+	Hs
		1042167 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL6_HUMAN (39-488): 2.14e-63: 221: 30.91
+	Hs
		152489 CUL3_HUMAN (1-768): 0: 951: 100.00		ENC1_HUMAN (31-578): 3.15e-45: 171: 26.26
+	Hs
		1041986 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL7_HUMAN (39-516): 1.5e-44: 169: 25.05
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL2_HUMAN (388-600): 1.72e-37: 148: 20.00
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (422-601): 4.03e-33: 135: 18.52
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH12_HUMAN (266-442): 5.66e-27: 117: 20.90
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH17_HUMAN (227-440): 9.47e-22: 101: 16.36
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (227-440): 1.16e-21: 101: 16.36
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (203-441): 5.27e-21: 99.1: 11.30
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH24_HUMAN (375-594): 9.91e-21: 98.4: 14.78
+	Hs
		1042324 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL5_HUMAN (462-600): 1.29e-17: 88.7: 11.51
+	Hs
		1042057 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH23_HUMAN (443-594): 1e-16: 85.7: 14.91