HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: RN138 (Q8WVD3)
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
Gene: RNF138

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016055 - Wnt signaling pathway GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 245
+	Hs
		1042230 CUL3_HUMAN (1-768): 0: 951: 100.00		RN166_HUMAN (5-244): 4.23e-40: 140: 29.58
+	Hs
		1042930 CUL3_HUMAN (1-768): 0: 951: 100.00		RN114_HUMAN (16-241): 4.34e-36: 129: 30.53
+	Hs
		1042922 CUL3_HUMAN (1-768): 0: 951: 100.00		TRAF6_HUMAN (12-245): 1.55e-33: 128: 16.25
+	Hs
		1019300 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI26_HUMAN (4-239): 2.73e-33: 127: 15.64
+	Hs
		584956 CUL3_HUMAN (1-768): 0: 951: 100.00		RO52_HUMAN (6-157): 6.92e-32: 123: 17.11
+	Hs
		129560 CUL3_HUMAN (1-768): 0: 951: 100.00		TRAF5_HUMAN (8-245): 3.76e-30: 119: 15.06
+	Hs
		1024672 CUL3_HUMAN (1-768): 0: 951: 100.00		TRAF3_HUMAN (2-245): 1.23e-28: 115: 14.69
+	Hs
		1041794 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI68_HUMAN (4-235): 8.64e-29: 115: 14.94
+	Hs
		1042261 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI11_HUMAN (9-171): 4.13e-29: 115: 12.50
+	Hs
		1042483 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM4_HUMAN (10-142): 6.25e-29: 115: 13.33
+	Hs
		1042482 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM5_HUMAN (5-160): 2.04e-28: 113: 14.91
+	Hs
		1042536 CUL3_HUMAN (1-768): 0: 951: 100.00		RNF41_HUMAN (1-158): 7.35e-29: 112: 20.96
+	Hs
		1042435 CUL3_HUMAN (1-768): 0: 951: 100.00		TRAF4_HUMAN (8-207): 1.85e-27: 111: 13.14
+	Hs
		1042709 CUL3_HUMAN (1-768): 0: 951: 100.00		KCMF1_HUMAN (147-236): 1.38e-25: 105: 32.22
+	Hs
		1042851 CUL3_HUMAN (1-768): 0: 951: 100.00		PZRN3_HUMAN (1-164): 4.32e-25: 105: 18.79
+	Hs
		551439 CUL4A_HUMAN (10-768): 0: 791: 38.32		RAG1_HUMAN (8-147): 1.08e-26: 110: 19.31
+	Hs
		1041301 CUL1_HUMAN (18-768): 0: 707: 30.57		TRAF6_HUMAN (12-245): 1.55e-33: 128: 16.25
+	Hs
		584955 CUL1_HUMAN (18-768): 0: 707: 30.57		RO52_HUMAN (6-157): 6.92e-32: 123: 17.11
+	Mm
		936275 CUL5_MOUSE (25-768): 0: 597: 23.40		TRAF6_MOUSE (12-227): 4.49e-33: 127: 15.77
+	Hs
		1274025 CUL5_HUMAN (25-768): 0: 597: 23.77		RING2_HUMAN (2-188): 8.11e-29: 112: 18.72