HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KLHL6 (Q8WZ60)
Kelch-like protein 6
Gene: KLHL6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	28807996, 29695787
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 621
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH24_HUMAN (18-607): 4.14e-165: 486: 43.94
+	Hs
		1042722 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL9_HUMAN (35-604): 2.6e-153: 456: 25.68
+	Hs
		1042720 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL8_HUMAN (34-621): 1.41e-146: 439: 23.50
+	Hs
		1042057 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH23_HUMAN (49-604): 8.06e-78: 259: 30.94
+	Hs
		152489 CUL3_HUMAN (1-768): 0: 951: 100.00		ENC1_HUMAN (62-581): 1.03e-74: 251: 29.96
+	Hs
		1042083 CUL3_HUMAN (1-768): 0: 951: 100.00		KBTB8_HUMAN (62-523): 2.22e-63: 221: 30.91
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (419-614): 6.06e-49: 182: 27.45
+	Hs
		1042324 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL5_HUMAN (468-619): 2.33e-36: 147: 22.29
+	Hs
		1042624 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL1_HUMAN (468-619): 1.51e-35: 144: 22.93
+	Hs
		1042489 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL4_HUMAN (452-619): 2.83e-35: 143: 21.97
+	Hs
		1041718 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH26_HUMAN (407-615): 7.51e-35: 141: 20.63
+	Hs
		1042674 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH28_HUMAN (454-620): 2.85e-34: 139: 15.59
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL2_HUMAN (472-618): 1.78e-28: 122: 21.05
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (497-618): 1.78e-23: 106: 20.16
+	Hs
		1042508 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH25_HUMAN (452-615): 6e-22: 102: 17.98
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (511-619): 6.6e-19: 92.9: 23.85
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH17_HUMAN (511-619): 2.53e-18: 91: 23.85
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (518-613): 1.42e-16: 85.2: 19.61
+	Hs
		1042027 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH36_HUMAN (515-618): 3.02e-14: 77.9: 13.79
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH12_HUMAN (544-614): 1.41e-09: 62.9: 19.72