HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: REQU (Q92785)
Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)
Gene: DPF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005813 - centrosome GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 391
+	Hs
		1042849 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI33_HUMAN (6-389): 8.72e-52: 188: 12.66
+	Hs
		1041592 CUL3_HUMAN (1-768): 0: 951: 100.00		CHD4_HUMAN (32-382): 5.17e-44: 165: 12.73
+	Hs
		782342 CUL3_HUMAN (1-768): 0: 951: 100.00		KDM5C_HUMAN (122-391): 3.54e-38: 148: 21.69
+	Hs
		170357 CUL3_HUMAN (1-768): 0: 951: 100.00		TIF1A_HUMAN (25-391): 1.7e-32: 131: 14.06
+	Hs
		152641 CUL3_HUMAN (1-768): 0: 951: 100.00		KMT2D_HUMAN (241-382): 8.36e-23: 102: 30.77
+	Hs
		1042076 CUL3_HUMAN (1-768): 0: 951: 100.00		KMT2C_HUMAN (266-376): 2.95e-09: 61.3: 22.22
+	Hs
		1042986 CUL4A_HUMAN (10-768): 0: 791: 38.32		CHD4_HUMAN (32-382): 5.17e-44: 165: 12.73
+	Hs
		1043519 CUL4B_HUMAN (5-768): 0: 779: 36.77		NSD1_HUMAN (101-375): 8.5e-35: 138: 17.97
+	Hs
		975302 CUL5_HUMAN (25-768): 0: 597: 23.77		KMT2A_HUMAN (80-388): 8.66e-36: 141: 14.38