HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: HIC2 (Q96JB3)
Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30)
Gene: HIC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BTB~Cullin
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 615
+	Hs
		781364 CUL3_HUMAN (1-768): 0: 951: 100.00		BCL6_HUMAN (23-614): 5.08e-117: 365: 21.93
+	Hs
		983757 CUL3_HUMAN (1-768): 0: 951: 100.00		ZNF91_HUMAN (147-614): 6.2e-110: 358: 17.23
+	Hs
		563806 CUL3_HUMAN (1-768): 0: 951: 100.00		ZNF30_HUMAN (67-469): 1.33e-99: 318: 10.85
+	Hs
		1041578 CUL3_HUMAN (1-768): 0: 951: 100.00		ZN268_HUMAN (67-360): 2.32e-59: 215: 9.67
+	Hs
		846676 CUL3_HUMAN (1-768): 0: 951: 100.00		ZNF84_HUMAN (63-305): 1.22e-40: 159: 10.29
+	Hs
		549161 CUL3_HUMAN (1-768): 0: 951: 100.00		ZN250_HUMAN (107-385): 5.86e-27: 117: 9.57
+	Hs
		67426 CUL3_HUMAN (1-768): 0: 951: 100.00		ZN850_HUMAN (67-241): 1.61e-24: 111: 10.11
+	Hs
		970659 CUL3_HUMAN (1-768): 0: 951: 100.00		ZNF45_HUMAN (515-615): 7.13e-22: 102: 29.70
+	Hs
		1024288 CUL3_HUMAN (1-768): 0: 951: 100.00		ZBT17_HUMAN (107-391): 5.36e-21: 99.8: 10.84
+	Hs
		1041579 CUL3_HUMAN (1-768): 0: 951: 100.00		ZN234_HUMAN (67-237): 1.19e-20: 98.2: 7.07
+	Hs
		73009 CUL3_HUMAN (1-768): 0: 951: 100.00		ZN879_HUMAN (106-355): 1.31e-20: 97.9: 8.77
+	Hs
		983972 CUL3_HUMAN (1-768): 0: 951: 100.00		ZBT16_HUMAN (385-504): 2.43e-19: 94: 14.17
+	Hs
		1041657 CUL3_HUMAN (1-768): 0: 951: 100.00		ZKSC8_HUMAN (272-424): 7.93e-19: 92.1: 13.64
+	Hs
		1041577 CUL3_HUMAN (1-768): 0: 951: 100.00		ZN267_HUMAN (501-612): 5.01e-15: 80.5: 30.28
+	Hs
		240841 CUL3_HUMAN (1-768): 0: 951: 100.00		Z354A_HUMAN (501-612): 4.15e-14: 77.4: 35.71
+	Hs
		1041728 CUL3_HUMAN (1-768): 0: 951: 100.00		ZN805_HUMAN (127-347): 5.37e-13: 74: 8.60
+	Hs
		200252 CUL3_HUMAN (1-768): 0: 951: 100.00		ZN264_HUMAN (127-361): 4.84e-13: 74: 9.36
+	Hs
		73014 CUL3_HUMAN (1-768): 0: 951: 100.00		B4DU56_HUMAN (67-161): 9.49e-10: 63.5: 10.19
+	Hs
		150366 CUL3_HUMAN (1-768): 0: 951: 100.00		ZN195_HUMAN (499-594): 5.38e-09: 61.2: 32.29
+	Hs
		1041610 CUL3_HUMAN (1-768): 0: 951: 100.00		OZF_HUMAN (551-612): 3.21e-09: 60.5: 43.55