HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KLH15 (Q96M94)
Kelch-like protein 15
Gene: KLHL15

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.963

Property	Details
Experiments	27561354, 28514442, 33130828, 33961781, 35563538, 21145461, 23135275
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0031463 - Cul3-RING ubiquitin ligase complex GO:0071630 - nuclear protein quality control by the ubiquitin-proteasome system
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 604
+	Hs
		1041715 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH22_HUMAN (8-602): 0: 540: 29.56
+	Hs
		1042324 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL5_HUMAN (1-593): 7.49e-155: 465: 24.12
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (3-603): 3.56e-147: 440: 23.06
+	Hs
		1042027 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH36_HUMAN (2-591): 4.28e-147: 440: 26.25
+	Hs
		1042624 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL1_HUMAN (8-593): 2.58e-145: 440: 22.11
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (19-592): 1.16e-142: 428: 22.76
+	Hs
		1042489 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL4_HUMAN (4-593): 5.83e-141: 428: 21.66
+	Hs
		1042720 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL8_HUMAN (4-590): 2.29e-140: 423: 22.26
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL2_HUMAN (10-587): 3.25e-140: 421: 23.25
+	Hs
		1041718 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH26_HUMAN (8-596): 3.6e-137: 414: 29.53
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH24_HUMAN (4-591): 7.18e-134: 405: 20.88
+	Hs
		1042016 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH34_HUMAN (8-599): 1.7e-56: 203: 26.07
+	Hs
		1042167 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL6_HUMAN (20-573): 9.8e-48: 178: 24.48
+	Hs
		1042722 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL9_HUMAN (102-476): 2.26e-36: 146: 12.28
+	Hs
		1042727 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH13_HUMAN (132-476): 1.01e-34: 141: 11.36
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (269-425): 1.34e-27: 119: 16.56
+	Hs
		1042674 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH28_HUMAN (270-424): 3.7e-26: 114: 20.00
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH12_HUMAN (410-600): 1.34e-22: 103: 20.00
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH17_HUMAN (490-603): 2.58e-15: 81.4: 19.30
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (238-377): 2.48e-10: 65.3: 15.00