HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: NLRP3 (Q96P20)
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)
Gene: NLRP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36936774
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006954 - inflammatory response GO:0016020 - membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1036
+	Hs
		1043169 CUL4A_HUMAN (10-768): 0: 791: 38.32		NLRP3_HUMAN (1-1036): 0: 881: 100.00
+	Hs
		1043523 CUL4B_HUMAN (5-768): 0: 779: 36.77		NLRP3_HUMAN (1-1036): 0: 881: 100.00
+	Hs
		1041151 CUL1_HUMAN (18-768): 0: 707: 30.57		NLRP3_HUMAN (1-1036): 0: 881: 100.00
+	Hs
		527987 CUL3_HUMAN (1-768): 0: 951: 100.00		RINI_HUMAN (800-1035): 1.2e-31: 131: 33.90
+	Hs
		1042479 CUL3_HUMAN (1-768): 0: 951: 100.00		NLRP1_HUMAN (897-1031): 5.84e-21: 101: 35.56
+	Hs
		1041938 CUL3_HUMAN (1-768): 0: 951: 100.00		NLRX1_HUMAN (826-1021): 4.41e-13: 75.9: 23.23
+	Hs
		702488 CUL3_HUMAN (1-768): 0: 951: 100.00		C2TA_HUMAN (886-1031): 2.1e-11: 70.5: 23.84
+	Hs
		1043203 CUL4A_HUMAN (10-768): 0: 791: 38.32		NLRP1_HUMAN (897-1031): 5.84e-21: 101: 35.56
+	Hs
		1043563 CUL4B_HUMAN (5-768): 0: 779: 36.77		NLRP1_HUMAN (897-1031): 5.84e-21: 101: 35.56
+	Hs
		1041076 CUL1_HUMAN (18-768): 0: 707: 30.57		NLRC5_HUMAN (745-1034): 6.36e-14: 79: 17.47
+	Hs
		702487 CUL1_HUMAN (18-768): 0: 707: 30.57		C2TA_HUMAN (886-1031): 2.1e-11: 70.5: 23.84
+	Hs
		1041384 CUL2_HUMAN (30-768): 0: 672: 26.17		NLRC5_HUMAN (745-1034): 6.36e-14: 79: 17.47