HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: TRIM9 (Q9C026)
E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING finger protein 91) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9)
Gene: TRIM9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 710
+	Hs
		1041873 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI67_HUMAN (4-700): 4.16e-154: 467: 60.98
+	Hs
		175678 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI18_HUMAN (1-709): 4.89e-141: 430: 24.02
+	Hs
		1042797 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM1_HUMAN (1-708): 7.26e-132: 408: 22.48
+	Hs
		1042604 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI36_HUMAN (1-699): 1.3e-105: 339: 22.25
+	Hs
		1042145 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI41_HUMAN (1-693): 3.14e-74: 253: 12.23
+	Hs
		170357 CUL3_HUMAN (1-768): 0: 951: 100.00		TIF1A_HUMAN (9-588): 1.42e-68: 245: 12.50
+	Hs
		1041564 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI25_HUMAN (77-694): 1.29e-70: 244: 14.87
+	Hs
		1041546 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI14_HUMAN (227-693): 5.45e-66: 226: 15.84
+	Hs
		1042849 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI33_HUMAN (81-461): 1.69e-60: 222: 14.92
+	Hs
		734621 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI23_HUMAN (119-420): 6.71e-63: 221: 20.88
+	Hs
		301806 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI37_HUMAN (156-519): 2.44e-43: 170: 20.56
+	Hs
		1042483 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM4_HUMAN (2-153): 3.2e-28: 121: 13.82
+	Hs
		262172 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM3_HUMAN (1-709): 7.49e-28: 121: 11.53
+	Hs
		1019300 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI26_HUMAN (1-153): 4.21e-27: 118: 13.73
+	Hs
		1042482 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM5_HUMAN (3-164): 1.38e-25: 113: 14.37
+	Hs
		1042484 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM2_HUMAN (8-709): 7.28e-24: 109: 11.17
+	Hs
		584956 CUL3_HUMAN (1-768): 0: 951: 100.00		RO52_HUMAN (1-164): 3.45e-24: 108: 15.24
+	Hs
		1041794 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI68_HUMAN (1-164): 6.08e-24: 107: 13.02
+	Hs
		1042261 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI11_HUMAN (3-147): 2.98e-20: 96.3: 17.93
+	Hs
		536817 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI27_HUMAN (2-163): 2.41e-16: 84.7: 19.75