HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: TRIM4 (Q9C037)
E3 ubiquitin-protein ligase TRIM4 (EC 2.3.2.27) (RING finger protein 87) (RING-type E3 ubiquitin transferase TRIM4) (Tripartite motif-containing protein 4)
Gene: TRIM4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 500
+	Hs
		584956 CUL3_HUMAN (1-768): 0: 951: 100.00		RO52_HUMAN (3-495): 1.15e-137: 407: 33.07
+	Hs
		1042261 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI11_HUMAN (5-498): 1.3e-126: 378: 35.07
+	Hs
		1041794 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI68_HUMAN (3-500): 3.69e-124: 373: 28.05
+	Hs
		536817 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI27_HUMAN (3-498): 8.55e-122: 368: 27.96
+	Hs
		135024 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI38_HUMAN (2-498): 2.42e-114: 347: 29.27
+	Hs
		1042482 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM5_HUMAN (3-497): 4.47e-112: 342: 26.05
+	Hs
		536818 CUL4B_HUMAN (5-768): 0: 779: 36.77		TRI27_HUMAN (3-498): 8.55e-122: 368: 27.96
+	Hs
		584955 CUL1_HUMAN (18-768): 0: 707: 30.57		RO52_HUMAN (3-495): 1.15e-137: 407: 33.07
+	Hs
		1019300 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI26_HUMAN (6-385): 8.99e-40: 152: 32.01
+	Hs
		477688 CUL1_HUMAN (18-768): 0: 707: 30.57		TRI49_HUMAN (3-485): 2.15e-101: 313: 26.59
+	Hs
		1042145 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI41_HUMAN (3-40): 3.95e-09: 61.1: 63.16
+	Hs
		536962 CUL5_HUMAN (25-768): 0: 597: 23.77		TRI27_HUMAN (3-498): 8.55e-122: 368: 27.96