HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: BTBD1 (Q9H0C5)
BTB/POZ domain-containing protein 1 (Hepatitis C virus NS5A-transactivated protein 8) (HCV NS5A-transactivated protein 8)
Gene: BTBD1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.980

Property	Details
Experiments	28514442, 33961781, 19995937, 32296183, 34878901, 35563538, 17543862, 21145461, 19295130, 25011449, unassigned1304, 34591642, 37207277
Identification Methods	affinity chromatography technology, two hybrid, tandem affinity purification, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 482
+	Hs
		1042454 CUL3_HUMAN (1-768): 0: 951: 100.00		BTBD2_HUMAN (41-482): 2.73e-131: 392: 82.17
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH12_HUMAN (49-481): 1.12e-119: 363: 17.44
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH24_HUMAN (26-480): 7.21e-111: 342: 15.89
+	Hs
		1042296 CUL3_HUMAN (1-768): 0: 951: 100.00		BTBD6_HUMAN (41-481): 2.49e-110: 338: 44.72
+	Hs
		1042167 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL6_HUMAN (4-480): 6.65e-109: 337: 16.21
+	Hs
		1042026 CUL3_HUMAN (1-768): 0: 951: 100.00		Q8N4I8_HUMAN (48-327): 1.46e-89: 277: 21.33
+	Hs
		1042083 CUL3_HUMAN (1-768): 0: 951: 100.00		KBTB8_HUMAN (12-291): 1.96e-85: 276: 21.13
+	Hs
		1041718 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH26_HUMAN (43-340): 2.93e-81: 265: 23.03
+	Hs
		1041986 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL7_HUMAN (59-337): 1.45e-79: 260: 24.48
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (57-299): 8.67e-77: 253: 21.55
+	Hs
		1042329 CUL3_HUMAN (1-768): 0: 951: 100.00		BTBD9_HUMAN (55-302): 4.97e-24: 107: 28.46
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL2_HUMAN (322-472): 1.44e-22: 102: 15.69
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (327-472): 2.82e-22: 102: 10.26
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH17_HUMAN (327-472): 5.94e-22: 101: 10.26
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (325-470): 3.91e-20: 95.6: 13.46
+	Hs
		1042324 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL5_HUMAN (303-472): 2.24e-19: 93.3: 9.44
+	Hs
		238083 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH41_HUMAN (62-285): 2.66e-14: 77.4: 25.76
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (327-478): 8.46e-14: 75.6: 11.84
+	Hs
		1042149 CUL3_HUMAN (1-768): 0: 951: 100.00		KBTB7_HUMAN (50-255): 3.91e-12: 70.5: 28.04
+	Hs
		1042489 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL4_HUMAN (335-476): 4.71e-10: 64: 9.79