HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: YTDC2 (Q9H6S0)
3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2)
Gene: YTHDC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 1430
+	Hs
		1041574 CUL3_HUMAN (1-768): 0: 951: 100.00		DHX8_HUMAN (25-482): 1.24e-127: 428: 22.61
+	Hs
		1042185 CUL3_HUMAN (1-768): 0: 951: 100.00		PRP16_HUMAN (25-482): 4.04e-118: 402: 22.57
+	Hs
		195426 CUL3_HUMAN (1-768): 0: 951: 100.00		DHX15_HUMAN (164-482): 6.33e-112: 374: 26.65
+	Hs
		1042520 CUL3_HUMAN (1-768): 0: 951: 100.00		DHX36_HUMAN (71-521): 4.15e-100: 346: 27.63
+	Hs
		994155 CUL3_HUMAN (1-768): 0: 951: 100.00		DHX9_HUMAN (119-458): 1.05e-90: 323: 32.77
+	Mm
		250467 CUL3_MOUSE (1-768): 0: 949: 99.48		DHX9_MOUSE (86-458): 4.29e-83: 302: 30.73
+	Hs
		195427 CUL4A_HUMAN (10-768): 0: 791: 38.32		DHX15_HUMAN (164-482): 6.33e-112: 374: 26.65
+	Hs
		195428 CUL4B_HUMAN (5-768): 0: 779: 36.77		DHX15_HUMAN (164-482): 6.33e-112: 374: 26.65
+	Hs
		1041892 CUL3_HUMAN (1-768): 0: 951: 100.00		DHX30_HUMAN (163-405): 4.25e-41: 167: 39.39
+	Hs
		994156 CUL4A_HUMAN (10-768): 0: 791: 38.32		DHX9_HUMAN (119-458): 1.05e-90: 323: 32.77
+	Hs
		994157 CUL4B_HUMAN (5-768): 0: 779: 36.77		DHX9_HUMAN (119-458): 1.05e-90: 323: 32.77
+	Hs
		195424 CUL1_HUMAN (18-768): 0: 707: 30.57		DHX15_HUMAN (164-482): 6.33e-112: 374: 26.65
+	Hs
		195425 CUL2_HUMAN (30-768): 0: 672: 26.17		DHX15_HUMAN (164-482): 6.33e-112: 374: 26.65
+	Hs
		994153 CUL1_HUMAN (18-768): 0: 707: 30.57		DHX9_HUMAN (119-458): 1.05e-90: 323: 32.77
+	Hs
		994154 CUL2_HUMAN (30-768): 0: 672: 26.17		DHX9_HUMAN (119-458): 1.05e-90: 323: 32.77
+	Hs
		195508 CUL5_HUMAN (25-768): 0: 597: 23.77		DHX15_HUMAN (164-482): 6.33e-112: 374: 26.65
+	Hs
		1043428 CUL4B_HUMAN (5-768): 0: 779: 36.77		DHX30_HUMAN (163-405): 4.25e-41: 167: 39.39
+	Hs
		994277 CUL5_HUMAN (25-768): 0: 597: 23.77		DHX9_HUMAN (119-458): 1.05e-90: 323: 32.77
+	Hs
		1041063 CUL1_HUMAN (18-768): 0: 707: 30.57		DHX30_HUMAN (163-405): 4.25e-41: 167: 39.39
+	Hs
		1183962 CUL5_HUMAN (25-768): 0: 597: 23.77		DHX30_HUMAN (163-405): 4.25e-41: 167: 39.39