HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: ARHGC (Q9NZN5)
Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
Gene: ARHGEF12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	21670212, 35563538
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1544
+	Hs
		1042210 CUL3_HUMAN (1-768): 0: 951: 100.00		ARHG2_HUMAN (557-1462): 1.89e-101: 351: 17.54
+	Hs
		1042328 CUL3_HUMAN (1-768): 0: 951: 100.00		PKH4B_HUMAN (376-1209): 4.85e-98: 350: 15.21
+	Hs
		1016910 CUL3_HUMAN (1-768): 0: 951: 100.00		AKP13_HUMAN (623-1216): 1.04e-92: 336: 23.13
+	Hs
		1042817 CUL3_HUMAN (1-768): 0: 951: 100.00		VAV3_HUMAN (726-1293): 4.2e-84: 297: 13.29
+	Hs
		1042307 CUL3_HUMAN (1-768): 0: 951: 100.00		FGD4_HUMAN (565-1372): 7.21e-82: 288: 14.29
+	Hs
		279863 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIO_HUMAN (776-1451): 2.3e-60: 232: 13.39
+	Hs
		855795 CUL4A_HUMAN (10-768): 0: 791: 38.32		VAV2_HUMAN (714-1339): 2.94e-93: 325: 13.81
+	Hs
		166484 CUL4B_HUMAN (5-768): 0: 779: 36.77		MCF2L_HUMAN (384-1307): 1.05e-85: 308: 14.27
+	Hs
		224713 CUL4A_HUMAN (10-768): 0: 791: 38.32		KALRN_HUMAN (776-1440): 2.07e-72: 271: 14.64
+	Dm
		115202 Q9V9R2_DROME (30-768): 0: 612: 24.52		M9PEF7_DROME (429-1201): 5.72e-91: 329: 15.32