HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: IBTK (Q9P2D0)
Inhibitor of Bruton tyrosine kinase (IBtk)
Gene: IBTK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	25882842, 29695787, 29395067, 28514442, 33130828, 33961781, 34878901, 35563538, 21145461, 34591642
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BTB~Cullin
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 1353
+	Mm
		1169620 CUL3_MOUSE (1-768): 0: 949: 99.48		IBTK_MOUSE (1-1353): 0: 1037: 85.75
+	Hs
		781364 CUL3_HUMAN (1-768): 0: 951: 100.00		BCL6_HUMAN (736-1188): 2.12e-74: 264: 17.99
+	Hs
		1041780 CUL3_HUMAN (1-768): 0: 951: 100.00		BTBD8_HUMAN (505-1304): 1.32e-69: 260: 15.34
+	Hs
		214258 CUL3_HUMAN (1-768): 0: 951: 100.00		SPOP_HUMAN (707-933): 1.99e-70: 243: 24.23
+	Hs
		1041654 CUL3_HUMAN (1-768): 0: 951: 100.00		HERC1_HUMAN (130-455): 4.25e-63: 240: 20.59
+	Hs
		1041805 CUL3_HUMAN (1-768): 0: 951: 100.00		SPOPL_HUMAN (707-933): 7.7e-65: 227: 21.63
+	Hs
		307251 CUL3_HUMAN (1-768): 0: 951: 100.00		RCBT2_HUMAN (23-313): 7.66e-47: 179: 21.38
+	Hs
		1042791 CUL3_HUMAN (1-768): 0: 951: 100.00		HERC5_HUMAN (127-355): 7.82e-42: 169: 24.48
+	Hs
		1042070 CUL3_HUMAN (1-768): 0: 951: 100.00		RCBT1_HUMAN (19-313): 6.28e-42: 164: 19.16
+	Dm
		1213841 Q8IP45_DROME (17-768): 0: 868: 69.08		RDX_DROME (707-931): 3.24e-64: 237: 24.44
+	Hs
		578433 CUL3_HUMAN (1-768): 0: 951: 100.00		RCC1_HUMAN (47-411): 2.58e-39: 154: 18.81
+	Dm
		1359790 Q9V475_DROME (2-768): 0: 861: 68.77		RDX_DROME (707-931): 3.24e-64: 237: 24.44
+	At
		1226186 CUL3A_ARATH (9-768): 0: 842: 51.45		BPM1_ARATH (703-949): 5.57e-68: 236: 25.00
+	At
		1341268 CUL3A_ARATH (9-768): 0: 842: 51.45		BPM2_ARATH (732-947): 4.17e-64: 225: 27.04
+	At
		1226178 CUL3B_ARATH (9-768): 0: 826: 50.92		BPM1_ARATH (703-949): 5.57e-68: 236: 25.00
+	Hs
		214259 CUL4A_HUMAN (10-768): 0: 791: 38.32		SPOP_HUMAN (707-933): 1.99e-70: 243: 24.23
+	Hs
		1042651 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH11_HUMAN (761-922): 2.45e-12: 73.6: 30.41
+	Hs
		1043285 CUL4A_HUMAN (10-768): 0: 791: 38.32		HERC5_HUMAN (127-355): 7.82e-42: 169: 24.48
+	Hs
		1043636 CUL4B_HUMAN (5-768): 0: 779: 36.77		HERC5_HUMAN (127-355): 7.82e-42: 169: 24.48
+	Hs
		1043624 CUL4B_HUMAN (5-768): 0: 779: 36.77		RCC2_HUMAN (25-358): 4.99e-32: 134: 16.12