HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: WRP73 (Q9P2S5)
WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene)
Gene: WRAP73

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0030030 - cell projection organization GO:0072686 - mitotic spindle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 460
+	Hs
		903207 CUL3_HUMAN (1-768): 0: 951: 100.00		WDR5_HUMAN (270-456): 8.41e-45: 161: 16.04
+	Hs
		1042634 CUL3_HUMAN (1-768): 0: 951: 100.00		BRWD1_HUMAN (1-312): 1.22e-25: 112: 12.21
+	Hs
		197016 CUL3_HUMAN (1-768): 0: 951: 100.00		PRP4_HUMAN (50-360): 9.05e-22: 99: 13.75
+	Hs
		152875 CUL3_HUMAN (1-768): 0: 951: 100.00		APAF_HUMAN (1-108): 9.41e-16: 82.1: 14.41
+	Hs
		1042655 CUL3_HUMAN (1-768): 0: 951: 100.00		NLE1_HUMAN (1-76): 3.09e-15: 79.8: 17.95
+	Hs
		1042101 CUL3_HUMAN (1-768): 0: 951: 100.00		POC1B_HUMAN (1-86): 3.68e-15: 79.4: 17.05
+	Hs
		1043157 CUL4A_HUMAN (10-768): 0: 791: 38.32		SNR40_HUMAN (170-459): 4.37e-59: 199: 11.07
+	Hs
		1043509 CUL4B_HUMAN (5-768): 0: 779: 36.77		SNR40_HUMAN (170-459): 4.37e-59: 199: 11.07
+	Hs
		1016274 CUL4B_HUMAN (5-768): 0: 779: 36.77		TBL3_HUMAN (59-460): 2.55e-51: 187: 12.50
+	Hs
		903208 CUL4A_HUMAN (10-768): 0: 791: 38.32		WDR5_HUMAN (270-456): 8.41e-45: 161: 16.04
+	Hs
		1043085 CUL4A_HUMAN (10-768): 0: 791: 38.32		WDR5B_HUMAN (270-456): 2.27e-41: 151: 15.51
+	Hs
		903209 CUL4B_HUMAN (5-768): 0: 779: 36.77		WDR5_HUMAN (270-456): 8.41e-45: 161: 16.04
+	Hs
		792982 CUL4A_HUMAN (10-768): 0: 791: 38.32		LIS1_HUMAN (275-459): 3.43e-39: 147: 9.73
+	Hs
		1043441 CUL4B_HUMAN (5-768): 0: 779: 36.77		WDR5B_HUMAN (270-456): 2.27e-41: 151: 15.51
+	Hs
		1043252 CUL4A_HUMAN (10-768): 0: 791: 38.32		BRWD1_HUMAN (1-312): 1.22e-25: 112: 12.21
+	Hs
		1043064 CUL4A_HUMAN (10-768): 0: 791: 38.32		BRWD3_HUMAN (5-153): 1.08e-15: 82.3: 11.36
+	Hs
		1043114 CUL4A_HUMAN (10-768): 0: 791: 38.32		POC1B_HUMAN (1-86): 3.68e-15: 79.4: 17.05
+	Hs
		1043417 CUL4B_HUMAN (5-768): 0: 779: 36.77		BRWD3_HUMAN (5-153): 1.08e-15: 82.3: 11.36
+	Hs
		152876 CUL4B_HUMAN (5-768): 0: 779: 36.77		APAF_HUMAN (1-108): 9.41e-16: 82.1: 14.41
+	Hs
		1043469 CUL4B_HUMAN (5-768): 0: 779: 36.77		POC1B_HUMAN (1-86): 3.68e-15: 79.4: 17.05