HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: TRI33 (Q9UPN9)
E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)
Gene: TRIM33

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 1127
+	Hs
		170357 CUL3_HUMAN (1-768): 0: 951: 100.00		TIF1A_HUMAN (106-1127): 7.13e-146: 467: 44.94
+	Hs
		1042484 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM2_HUMAN (115-491): 4.9e-86: 296: 20.74
+	Hs
		1042797 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM1_HUMAN (98-496): 3.35e-71: 254: 17.21
+	Hs
		175678 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI18_HUMAN (117-493): 1.15e-70: 251: 17.65
+	Hs
		1042604 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI36_HUMAN (119-470): 1.35e-62: 229: 16.62
+	Hs
		668665 CUL3_HUMAN (1-768): 0: 951: 100.00		PML_HUMAN (83-635): 9.83e-61: 226: 17.01
+	Hs
		1042196 CUL3_HUMAN (1-768): 0: 951: 100.00		CBP_HUMAN (517-1061): 4.54e-59: 225: 15.06
+	Hs
		734621 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI23_HUMAN (91-479): 1.27e-59: 217: 16.20
+	Hs
		1042406 CUL3_HUMAN (1-768): 0: 951: 100.00		TRI56_HUMAN (110-616): 1.64e-56: 212: 18.25
+	Hs
		262172 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM3_HUMAN (179-629): 2.88e-56: 211: 16.02
+	Hs
		1042482 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM5_HUMAN (168-541): 1.28e-55: 203: 12.47
+	Hs
		1042481 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM9_HUMAN (150-517): 1.11e-53: 202: 14.06
+	Hs
		584956 CUL3_HUMAN (1-768): 0: 951: 100.00		RO52_HUMAN (178-518): 2.8e-54: 199: 13.91
+	Hs
		1042477 CUL3_HUMAN (1-768): 0: 951: 100.00		TRIM8_HUMAN (120-642): 2.09e-52: 195: 14.95
+	Hs
		1029397 CUL3_HUMAN (1-768): 0: 951: 100.00		TIF1B_HUMAN (631-1105): 6.36e-25: 114: 18.20
+	Hs
		668664 CUL1_HUMAN (18-768): 0: 707: 30.57		PML_HUMAN (83-635): 9.83e-61: 226: 17.01
+	Hs
		1041187 CUL1_HUMAN (18-768): 0: 707: 30.57		TRIM9_HUMAN (150-517): 1.11e-53: 202: 14.06
+	Hs
		584955 CUL1_HUMAN (18-768): 0: 707: 30.57		RO52_HUMAN (178-518): 2.8e-54: 199: 13.91
+	Hs
		1029398 CUL4A_HUMAN (10-768): 0: 791: 38.32		TIF1B_HUMAN (631-1105): 6.36e-25: 114: 18.20
+	Hs
		1029395 CUL1_HUMAN (18-768): 0: 707: 30.57		TIF1B_HUMAN (631-1105): 6.36e-25: 114: 18.20