HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: IRS2 (Q9Y4H2)
Insulin receptor substrate 2 (IRS-2)
Gene: IRS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1338
+	Hs
		724543 CUL3_HUMAN (1-768): 0: 951: 100.00		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Mm
		724626 CUL3_MOUSE (1-768): 0: 949: 99.48		IRS1_MOUSE (21-1164): 5.96e-79: 287: 32.74
+	Hs
		151793 CUL3_HUMAN (1-768): 0: 951: 100.00		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		1042196 CUL3_HUMAN (1-768): 0: 951: 100.00		CBP_HUMAN (278-1288): 4.81e-39: 161: 12.20
+	Hs
		151794 CUL4B_HUMAN (5-768): 0: 779: 36.77		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		1041909 CUL3_HUMAN (1-768): 0: 951: 100.00		TICRR_HUMAN (453-1197): 1.42e-14: 81.4: 13.74
+	Hs
		1042076 CUL3_HUMAN (1-768): 0: 951: 100.00		KMT2C_HUMAN (327-956): 7.92e-14: 79.1: 13.93
+	Hs
		724542 CUL1_HUMAN (18-768): 0: 707: 30.57		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Mm
		724629 CUL1_MOUSE (17-768): 0: 709: 30.53		IRS1_MOUSE (21-1164): 5.96e-79: 287: 32.74
+	Hs
		151791 CUL1_HUMAN (18-768): 0: 707: 30.57		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		151792 CUL2_HUMAN (30-768): 0: 672: 26.17		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Dm
		1359795 Q9V475_DROME (2-768): 0: 861: 68.77		Q9VLS7_DROME (276-1207): 2.09e-13: 77.6: 8.59