HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: NS1BP (Q9Y6Y0)
Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39)
Gene: IVNS1ABP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	25619834
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0097193 - intrinsic apoptotic signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 642
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH12_HUMAN (1-607): 1.66e-153: 456: 25.04
+	Hs
		1042720 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL8_HUMAN (2-604): 2.5e-143: 432: 23.68
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (157-639): 1.35e-80: 269: 22.43
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH17_HUMAN (404-639): 1.37e-60: 215: 36.44
+	Hs
		1042768 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL3_HUMAN (411-639): 5.1e-61: 215: 36.36
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (404-639): 1.02e-60: 215: 36.86
+	Hs
		1042674 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH28_HUMAN (401-641): 1.58e-60: 213: 29.80
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (417-641): 8.94e-60: 212: 37.28
+	Hs
		1042722 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL9_HUMAN (417-641): 4.91e-56: 202: 27.78
+	Hs
		1042727 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH13_HUMAN (417-641): 4.46e-55: 200: 28.63
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (444-639): 6.25e-53: 193: 37.56
+	Hs
		1042324 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL5_HUMAN (444-639): 2.91e-50: 188: 37.25
+	Hs
		1042489 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL4_HUMAN (419-639): 1.54e-49: 185: 31.22
+	Hs
		1042624 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL1_HUMAN (449-639): 3.33e-49: 185: 35.60
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH24_HUMAN (112-638): 5.81e-46: 173: 15.85
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL2_HUMAN (513-639): 1.14e-28: 123: 35.43
+	Hs
		1042508 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH25_HUMAN (461-641): 8.35e-28: 120: 25.52
+	Hs
		152489 CUL3_HUMAN (1-768): 0: 951: 100.00		ENC1_HUMAN (465-641): 1.8e-26: 116: 27.66
+	Hs
		1041718 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH26_HUMAN (448-634): 3.96e-14: 77.8: 26.73
+	Hs
		1041986 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL7_HUMAN (464-633): 1.09e-11: 69.7: 24.43