HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: SF3B3 (Q15393)
Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130)
Gene: SF3B3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23951410
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CPSF_A~Cullin, Cullin~MMS1_N
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 759 Hs			1 1217
+	Hs
		1041634 CUL3_HUMAN (32-759): 0: 814: 38.23		SF3B3_HUMAN (1-1217): 0: 1474: 100.00
+	Hs
		1040995 CUL1_HUMAN (59-759): 0: 745: 30.55		SF3B3_HUMAN (1-1217): 0: 1474: 100.00
+	Hs
		1041332 CUL2_HUMAN (51-759): 0: 710: 27.00		SF3B3_HUMAN (1-1217): 0: 1474: 100.00
+	Mm
		1111812 CUL4A_MOUSE (1-759): 0: 977: 95.13		DDB1_MOUSE (2-1211): 0: 1062: 21.02
+	Hs
		1043013 CUL4A_HUMAN (1-759): 0: 963: 100.00		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Hs
		1043374 CUL4B_HUMAN (10-759): 0: 927: 82.31		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Mm
		56795 CUL4B_MOUSE (10-759): 0: 927: 82.18		DDB1_MOUSE (2-1211): 0: 1062: 21.02
+	At
		1228145 CUL4_ARATH (24-759): 0: 861: 57.40		DDB1A_ARATH (2-1211): 0: 1039: 20.03
+	At
		221829 CUL4_ARATH (24-759): 0: 861: 57.40		DDB1B_ARATH (1-1211): 0: 1032: 20.10
+	Hs
		1041668 CUL3_HUMAN (32-759): 0: 814: 38.23		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Dm
		1124382 Q5BI50_DROME (27-759): 0: 877: 65.90		DDB1_DROME (2-1211): 0: 948: 19.94
+	Hs
		1041008 CUL1_HUMAN (59-759): 0: 745: 30.55		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Hs
		1082313 CUL5_HUMAN (59-759): 0: 589: 24.94		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Ce
		1088892 CUL4_CAEEL (10-759): 0: 665: 32.28		DDB1_CAEEL (3-1211): 0: 832: 18.50
+	Hs
		1014118 CUL4A_HUMAN (1-759): 0: 963: 100.00		CPSF1_HUMAN (701-1216): 4.42e-121: 410: 15.99
+	Sp
		143266 CUL4_SCHPO (37-755): 0: 638: 31.89		DDB1_SCHPO (4-1211): 0: 708: 15.42
+	Sp
		144468 CUL4_SCHPO (37-755): 0: 638: 31.89		RIK1_SCHPO (11-1179): 0: 629: 14.13
+	Hs
		1014117 CUL3_HUMAN (32-759): 0: 814: 38.23		CPSF1_HUMAN (701-1216): 4.42e-121: 410: 15.99