HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: DCAF6 (Q58WW2)
DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP)
Gene: DCAF6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	16949367, 28212551, 37689310, 36688959, 31973889, 16964240, 21145461, 19295130
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 860
+	Hs
		1043396 CUL4B_HUMAN (10-759): 0: 927: 82.31		DCAF6_HUMAN (1-860): 0: 569: 100.00
+	Mm
		1111816 CUL4A_MOUSE (1-759): 0: 977: 95.13		DCAF8_MOUSE (2-328): 4.5e-66: 233: 27.60
+	Hs
		1043043 CUL4A_HUMAN (1-759): 0: 963: 100.00		DCAF8_HUMAN (2-328): 8.4e-66: 232: 27.60
+	Mm
		1111813 CUL4A_MOUSE (1-759): 0: 977: 95.13		WDTC1_MOUSE (13-296): 5.07e-50: 189: 26.06
+	Hs
		1043405 CUL4B_HUMAN (10-759): 0: 927: 82.31		DCAF8_HUMAN (2-328): 8.4e-66: 232: 27.60
+	Hs
		473596 CUL4A_HUMAN (1-759): 0: 963: 100.00		DC8L2_HUMAN (709-852): 2.15e-51: 192: 35.14
+	Hs
		1043102 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDTC1_HUMAN (13-300): 3.67e-50: 190: 25.72
+	Hs
		473597 CUL4B_HUMAN (10-759): 0: 927: 82.31		DC8L2_HUMAN (709-852): 2.15e-51: 192: 35.14
+	Hs
		1043162 CUL4A_HUMAN (1-759): 0: 963: 100.00		DCAF5_HUMAN (28-223): 9.1e-23: 106: 25.37
+	Hs
		1043114 CUL4A_HUMAN (1-759): 0: 963: 100.00		POC1B_HUMAN (585-851): 2.28e-20: 97.3: 12.41
+	Hs
		1043068 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR82_HUMAN (34-282): 6.27e-17: 84.4: 19.54
+	Hs
		792982 CUL4A_HUMAN (1-759): 0: 963: 100.00		LIS1_HUMAN (655-815): 5.13e-15: 80: 13.04
+	Hs
		1043085 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5B_HUMAN (577-836): 4.46e-14: 76.1: 6.82
+	Hs
		863425 CUL4A_HUMAN (1-759): 0: 963: 100.00		COPA_HUMAN (716-804): 1.2e-12: 74.2: 16.30
+	Hs
		903208 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5_HUMAN (579-832): 1.37e-12: 71.9: 5.81
+	Hs
		1043157 CUL4A_HUMAN (1-759): 0: 963: 100.00		SNR40_HUMAN (704-816): 2.84e-10: 64.9: 21.24
+	Hs
		1043419 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR82_HUMAN (34-282): 6.27e-17: 84.4: 19.54
+	Hs
		929446 CUL4B_HUMAN (10-759): 0: 927: 82.31		RACK1_HUMAN (44-220): 2.63e-15: 79.8: 21.79
+	Hs
		1043441 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5B_HUMAN (577-836): 4.46e-14: 76.1: 6.82
+	Hs
		903209 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5_HUMAN (579-832): 1.37e-12: 71.9: 5.81