HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: CSN6 (Q7L5N1)
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
Gene: COPS6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.980

Property	Details
Experiments	30945288, 31973889, 33179082, 16964240, 17079684, 18606781, 21145461, 22474075, 19295130, 26186194, 28514442, 33961781, 19615732
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin_Nedd8~JAB
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 759 Hs			1 327
+	Hs
		1043429 CUL4B_HUMAN (10-759): 0: 927: 82.31		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		91398 CUL4B_HUMAN (10-759): 0: 927: 82.31		E7EM64_HUMAN (1-327): 1.07e-139: 399: 99.69
+	Hs
		1041897 CUL3_HUMAN (32-759): 0: 814: 38.23		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		177020 CUL4A_HUMAN (1-759): 0: 963: 100.00		EIF3H_HUMAN (33-305): 9.03e-59: 194: 14.38
+	Hs
		1041064 CUL1_HUMAN (59-759): 0: 745: 30.55		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		124855 CUL3_HUMAN (32-759): 0: 814: 38.23		EIF3F_HUMAN (10-306): 1.15e-110: 327: 22.07
+	Hs
		1041373 CUL2_HUMAN (51-759): 0: 710: 27.00		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		849195 CUL3_HUMAN (32-759): 0: 814: 38.23		PSMD7_HUMAN (37-317): 1.48e-97: 292: 24.48
+	Hs
		1184935 CUL5_HUMAN (59-759): 0: 589: 24.94		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Ce
		954204 CUL3_CAEEL (35-759): 0: 740: 33.72		CSN5_CAEEL (29-253): 1.44e-51: 176: 11.95