HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: CAND1 (Q86VP6)
Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)
Gene: CAND1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.984

Property	Details
Experiments	27203177, 12609982, 12504025, 31973889, 36423380, 36688959, 16964240, 15448697, 21249194, 22405651, 12504026, 17079684, 18606781, 21145461, 22474075, 19295130
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cullin~TIP120
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 1230
+	Hs
		1043440 CUL4B_HUMAN (10-759): 0: 927: 82.31		CAND1_HUMAN (1-1230): 0: 922: 100.00
+	Hs
		1041947 CUL3_HUMAN (32-759): 0: 814: 38.23		CAND1_HUMAN (1-1230): 0: 922: 100.00
+	Hs
		1041074 CUL1_HUMAN (59-759): 0: 745: 30.55		CAND1_HUMAN (1-1230): 0: 922: 100.00
+	Mm
		1169688 CUL1_MOUSE (59-759): 0: 745: 30.55		CAND1_MOUSE (1-1230): 0: 920: 99.43
+	Hs
		256749 CUL3_HUMAN (32-759): 0: 814: 38.23		CAND2_HUMAN (1-1230): 0: 830: 62.25
+	Hs
		1041383 CUL2_HUMAN (51-759): 0: 710: 27.00		CAND1_HUMAN (1-1230): 0: 922: 100.00
+	At
		1226075 CUL4_ARATH (24-759): 0: 861: 57.40		CAND1_ARATH (4-1218): 0: 734: 42.73
+	Mm
		1169706 CUL1_MOUSE (59-759): 0: 745: 30.55		CAND2_MOUSE (1-1230): 0: 841: 60.47
+	Hs
		256748 CUL1_HUMAN (59-759): 0: 745: 30.55		CAND2_HUMAN (1-1230): 0: 830: 62.25
+	Dm
		1213848 Q8IP45_DROME (51-759): 0: 776: 36.20		CAND1_DROME (1-1230): 0: 781: 57.85
+	At
		1226078 CUL1_ARATH (57-759): 0: 744: 34.20		CAND1_ARATH (4-1218): 0: 734: 42.73
+	Ce
		105747 CUL3_CAEEL (35-759): 0: 740: 33.72		CAND1_CAEEL (4-1222): 0: 613: 35.74
+	Hs
		163605 CUL3_HUMAN (32-759): 0: 814: 38.23		BTAF1_HUMAN (32-1121): 7.24e-85: 307: 11.67
+	Hs
		787480 CUL4A_HUMAN (1-759): 0: 963: 100.00		MTOR_HUMAN (11-798): 1.42e-22: 107: 11.87
+	Hs
		268709 CUL3_HUMAN (32-759): 0: 814: 38.23		SF3B1_HUMAN (365-1153): 1.41e-55: 214: 12.32
+	Hs
		127264 CUL3_HUMAN (32-759): 0: 814: 38.23		IPO5_HUMAN (145-1127): 4.6e-35: 147: 10.95
+	Hs
		268708 CUL1_HUMAN (59-759): 0: 745: 30.55		SF3B1_HUMAN (365-1153): 1.41e-55: 214: 12.32
+	Hs
		155572 CUL3_HUMAN (32-759): 0: 814: 38.23		TNPO2_HUMAN (432-1148): 1.53e-15: 84.2: 12.59
+	Hs
		1042184 CUL3_HUMAN (32-759): 0: 814: 38.23		GCN1_HUMAN (8-396): 2.82e-11: 70.4: 12.69
+	Hs
		1042209 CUL3_HUMAN (32-759): 0: 814: 38.23		TNPO1_HUMAN (826-1148): 1.51e-09: 64.6: 12.21