HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: DCAF4 (Q8WV16)
DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A)
Gene: DCAF4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.751

Property	Details
Experiments	16949367, 28514442, 33961781, 37689310, 30945288, 32140073, 31973889, 16964240, 21145461
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 759 Hs			1 495
+	Hs
		1043475 CUL4B_HUMAN (10-759): 0: 927: 82.31		DCAF4_HUMAN (1-495): 0: 919: 100.00
+	Hs
		1043107 CUL4A_HUMAN (1-759): 0: 963: 100.00		DC4L2_HUMAN (101-494): 0: 694: 74.62
+	Hs
		1043028 CUL4A_HUMAN (1-759): 0: 963: 100.00		DC4L1_HUMAN (101-495): 0: 681: 76.77
+	Hs
		1043460 CUL4B_HUMAN (10-759): 0: 927: 82.31		DC4L2_HUMAN (101-494): 0: 694: 74.62
+	Hs
		1043387 CUL4B_HUMAN (10-759): 0: 927: 82.31		DC4L1_HUMAN (101-495): 0: 681: 76.77