HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: CSN8 (Q99627)
COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)
Gene: COPS8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.755

Property	Details
Experiments	28514442, 27173435, 33961781, 31973889, 36688959, 16964240, 17079684, 18606781, 21145461, 19295130
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 759 Hs			1 209
+	Hs
		1043536 CUL4B_HUMAN (10-759): 0: 927: 82.31		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1042368 CUL3_HUMAN (32-759): 0: 814: 38.23		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	At
		794514 CUL4_ARATH (24-759): 0: 861: 57.40		CSN8_ARATH (7-209): 9.28e-80: 238: 31.40
+	At
		794521 CUL3A_ARATH (36-759): 0: 853: 38.26		CSN8_ARATH (7-209): 9.28e-80: 238: 31.40
+	Hs
		1041162 CUL1_HUMAN (59-759): 0: 745: 30.55		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1041445 CUL2_HUMAN (51-759): 0: 710: 27.00		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1274027 CUL5_HUMAN (59-759): 0: 589: 24.94		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00