HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: SMAD5 (Q99717)
Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5)
Gene: SMAD5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36688959
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 759 Hs			1 465
+	Hs
		1043008 CUL4A_HUMAN (1-759): 0: 963: 100.00		SMAD2_HUMAN (4-465): 0: 530: 55.60
+	Hs
		1043369 CUL4B_HUMAN (10-759): 0: 927: 82.31		SMAD2_HUMAN (4-465): 0: 530: 55.60
+	Hs
		950170 CUL1_HUMAN (59-759): 0: 745: 30.55		SMAD3_HUMAN (4-465): 0: 550: 58.97
+	Hs
		1078616 CUL5_HUMAN (59-759): 0: 589: 24.94		SMAD2_HUMAN (4-465): 0: 530: 55.60
+	Hs
		167358 CUL4A_HUMAN (1-759): 0: 963: 100.00		SMAD7_HUMAN (31-132): 7.88e-27: 113: 31.58
+	Hs
		167359 CUL4B_HUMAN (10-759): 0: 927: 82.31		SMAD7_HUMAN (31-132): 7.88e-27: 113: 31.58
+	Hs
		206957 CUL2_HUMAN (51-759): 0: 710: 27.00		SMAD6_HUMAN (37-191): 4.62e-40: 152: 31.01